Short-term exposure to hydrogen peroxide during oocyte maturation improves bovine embryo development

Reproduction : the Official Journal of the Society for the Study of Fertility
L VandaeleAnn Van Soom

Abstract

Recent studies have shown that short-term exposure of oocytes to a stressor such as hydrostatic pressure or osmotic stress might induce stress tolerance in embryos. The aim of the present study was to investigate the consequences of short-term hydrogen peroxide (H(2)O(2)) exposure to bovine in vitro matured cumulus-oocyte complexes (COCs) on subsequent preimplantation embryo development and apoptosis. In the first experiment, mature COCs were incubated in H(2)O(2) at concentrations ranging between 0.01 and 100 micromol/l, and subsequently fertilized and cultured. Oocyte incubation with 50-100 micromol/l of H(2)O(2) resulted in a significantly higher blastocyst yield (47.3%) in comparison with control medium (31.8%), while apoptotic cell ratio was inversely related with H(2)O(2) concentration. In the second experiment, we showed that the stress tolerance after H(2)O(2) exposure was not mediated by increased glutathione content in treated oocytes nor by enhanced fertilization or penetration. Further research should concentrate on the potential role of players that have been associated with stress tolerance in somatic cell lines.

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Citations

Mar 28, 2012·The Journal of Reproduction and Development·Masashi Takahashi
Jan 19, 2013·Reproduction, Fertility, and Development·Mohammad Bozlur RahmanAnn Van Soom
Mar 4, 2011·Reproduction, Fertility, and Development·Csaba Pribenszky, Gabor Vajta
Aug 30, 2011·Reproduction, Fertility, and Development·Dorit Kalo, Zvi Roth
May 1, 2012·Reproduction, Fertility, and Development·Mohammad Bozlur RahmanAnn Van Soom
Oct 13, 2015·Theriogenology·Nathalia Nogueira da CostaOtávio Mitio Ohashi
Aug 1, 2012·Reproduction in Domestic Animals = Zuchthygiene·C PribenszkyG Vajta
Jun 7, 2011·Reproduction in Domestic Animals = Zuchthygiene·C PribenszkyO Szenci
Sep 12, 2014·Reproduction, Fertility, and Development·Alfonso Gutierrez-AdanMellissa R W Mann
Aug 26, 2014·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Laura BenagliaLuigi Fedele
Oct 21, 2016·In Vitro Cellular & Developmental Biology. Animal·Tong ZhangJiaxin Zhang
Jun 18, 2010·Biology of Reproduction·Csaba PribenszkyJohn Yovich
Jun 1, 2018·Cellular Reprogramming·Gábor Vajta
Jul 25, 2021·International Journal of Molecular Sciences·Alexander G Kuzma-HuntLaura A Favetta

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