PMID: 8614241Mar 3, 1995Paper

Short-term exposure to lipopolysaccharide is associated with microvascular contractile dysfunction in vivo

Life Sciences
X P GaoIsrael Rubinstein

Abstract

The purpose of this study was to determine whether short-term exposure of resistance arterioles to lipopolysaccharide in situ is associated with changes in vasomotor tone. Using intravital microscopy, we found that suffusion of Escherichia coli lipopolysaccharide (3 micrograms/ml) over hamster cheek pouch arterioles for 1 h was associated with a significant immediate biphasic response: vasoconstriction followed by vasodilation (p < 0.05). The former was attenuated by indomethacin, and the latter by SK&F 108566, a selective, non-peptide angiotension II receptor antagonist (p < 0.05). The nitric oxide synthase inhibitor, NG-L-nitro arginine, had no significant effects on lipopolysaccharide-induced responses. Allopurinol, a scavenger of reactive oxygen species, significantly attenuated lipopolysaccharide-induced vasodilation. Acetylcholine- and nitroglycerin-induced vasodilation were significantly potentiated after lipopolysaccharide. These responses were recorded in the absence of any significant changes in systemic arterial blood pressure. Collectively, these data suggest that short-term exposure of the peripheral microcirculation to lipopolysaccharide in situ is associated with an ischemia-reperfusion-like injury. These changes...Continue Reading

References

Jul 1, 1991·Journal of Applied Physiology·T MatsudaS I Rennard
Mar 1, 1993·The American Journal of Physiology·A J BakerM W Weiner

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Citations

Mar 15, 1997·Annals of the New York Academy of Sciences·D Weihrauch, W Riedel
Aug 16, 2001·Critical Reviews in Toxicology·E J Calabrese
Apr 1, 2006·Journal of Applied Physiology·Israel Rubinstein, Susanna G Von Essen
Nov 19, 2002·Perceptual and Motor Skills·Alberto Montare
Aug 4, 1998·The American Journal of Physiology·H IkezakiI Rubinstein
Sep 18, 2002·Journal of Applied Physiology·Takaya TsueshitaIsrael Rubinstein
Jun 16, 2001·Journal of Applied Physiology·H SuzukiI Rubinstein

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