Short-term exposure to nitrogen dioxide enhances susceptibility to murine respiratory mycoplasmosis and decreases intrapulmonary killing of Mycoplasma pulmonis

The American Review of Respiratory Disease
R F ParkerJ W Simecka

Abstract

In C57BL/6N and C3H/HeN mice known to be free of all murine pathogens and matched for age, sex, microbiologic, and environmental factors, exposure to NO2 for 4 h prior to exposure to infectious aerosols of Mycoplasma pulmonis resulted in potentiation of murine respiratory mycoplasmosis (MRM). In the C57BL/6N mice, NO2 increased the incidence of death, incidence of gross lung lesions, and incidence of microscopic lung lesions, but did not increase the incidence of infection in the lungs. Nitrogen dioxide affected the C3H/HeN mice (a strain known to be more susceptible than the C57BL/6N strain to MRM) similarly, with the exception that the incidence of death and microscopic lesions were not affected in this strain at the concentrations of M. pulmonis used. Exposure to the oxidant also increased the severity of microscopic lesions and the numbers of Mycoplasma organisms in the lungs of both mouse strains. Thus, NO2 appeared to affect host lung defense mechanisms responsible for limiting the extent of infection. The NO2 exposure level required to produce potentiation varied with the genetic background of the host, the number of Mycoplasma organisms administered, and the end point measured. In further experiments in C57BL/6N mice, e...Continue Reading

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Citations

Apr 1, 1992·Journal of Toxicology and Environmental Health·K MochitateT Miura
Sep 24, 2005·Infection and Immunity·Matthew D WoolardJerry W Simecka
Jan 1, 2005·American Journal of Respiratory Cell and Molecular Biology·Monica Fonseca-AtenR Doug Hardy
Nov 17, 2006·Environmental Health Perspectives·Robert E DalesMarc Smith Doiron
Aug 26, 1998·Emerging Infectious Diseases·G H Cassell
Aug 6, 1999·Environmental Research·S Becker, J M Soukup
Jul 8, 1999·The American Journal of Pathology·T J MurphyD M McDonald
Oct 1, 1991·Environmental Research·J SchwartzE Malin
Dec 29, 2017·Annals of the American Thoracic Society·Cheryl S PirozziNathan C Dean
May 25, 2020·The Journal of Infection·Antonio FronteraGeorge Cremona
Jan 1, 1993·Clinical Microbiology Reviews·G H CassellR Harasawa
Nov 1, 1990·Infection and Immunity·D T CrouseG Cassady
Dec 1, 1996·Infection and Immunity·S C CartnerJ R Lindsey

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