Short-term exposures to dihaloacetic acids produce dysmorphogenesis in mouse conceptuses in vitro

Reproductive Toxicology
E Sidney HunterNeil Chernoff

Abstract

The haloacetic acids (HAAs) are a family of xenobiotics found in tap water as a result of drinking water disinfection. Administration of HAAs to rats produces a variety of adverse effects, including developmental toxicity. The dysmorphogenic potencies of all nine bromo/chloro-acetic acids have been determined in rodent whole embryo culture using standard 26-h exposure. Since the half-lives of the HAAs in vivo are typically <8 h, the developmental effects of short-term exposures to dihaloacetates were evaluated. Gestation day 8 (3-6 somite pairs) CD-1 mouse conceptuses were exposed to 11,000 microM dichloroacetic acid (DCA), 300 microM dibromoacetic acid (DBA) or 300 microM bromochloroacetic acid (BCA) for culture periods of 1, 3, 6 or 26 h. Following 1, 3 or 6 h of exposure to HAAs, conceptuses were transferred to control medium to complete a 26-h culture period. The amounts of HAAs present in embryos after 1, 3 and 6h of exposure were determined. Increased incidences of dysmorphic embryos were produced by 6 or 26-h exposures to DCA; a 26-h exposure to DBA; or 3, 6 or 26-h exposures to BCA. The dysmorphology produced was dependent upon the length of exposure and chemical. The embryonic concentration of each HAA (104.5, 2.5 and ...Continue Reading

References

Sep 1, 1992·Teratology·M K SmithJ A Stober
Sep 1, 1992·Teratology·D L EpsteinM K Smith
Jul 1, 1991·Biopharmaceutics & Drug Disposition·S H CurryP W Stacpoole
Nov 1, 1989·Teratology·M K SmithJ A Stober
Aug 1, 1996·Teratology·E S HunterA Richard
Jul 17, 1999·Toxicology and Applied Pharmacology·I R SchultzR J Bull
Nov 19, 2005·Reproductive Toxicology·E Sidney HunterNeil Chernoff

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Citations

Jun 16, 2010·Environmental Toxicology·Murali K MallelaTerry C Hrubec
Nov 16, 2018·Journal of Biochemical and Molecular Toxicology·Omar IssaFrederick E Williams
Sep 25, 2021·Environmental Science and Pollution Research International·Zhihua ZhaoYang Yang

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