Short-term fasting, seizure control and brain amino acid metabolism

Neurochemistry International
Marc YudkoffItzhak Nissim

Abstract

The ketogenic diet is an effective treatment for seizures, but the mechanism of action is unknown. It is uncertain whether the anti-epileptic effect presupposes ketosis, or whether the restriction of calories and/or carbohydrate might be sufficient. We found that a relatively brief (24 h) period of low glucose and low calorie intake significantly attenuated the severity of seizures in young Sprague-Dawley rats (50-70 gms) in whom convulsions were induced by administration of pentylenetetrazole (PTZ). The blood glucose concentration was lower in animals that received less dietary glucose, but the brain glucose level did not differ from control blood [3-OH-butyrate] tended to be higher in blood, but not in brain, of animals on a low-glucose intake. The concentration in brain of glutamine increased and that of alanine declined significantly with low-glucose intake. The blood alanine level fell more than that of brain alanine, resulting in a marked increase ( approximately 50%) in the brain:blood ratio for alanine. In contrast, the brain:blood ratio for leucine declined by about 35% in the low-glucose group. When animals received [1-(13)C]glucose, a metabolic precursor of alanine, the appearance of (13)C in alanine and glutamine in...Continue Reading

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Citations

Dec 17, 2008·Epilepsia·Marc YudkoffItzhak Nissim
Jan 19, 2010·Annual Review of Pathology·Douglas C WallaceVincent Procaccio
Jan 23, 2016·Seizure : the Journal of the British Epilepsy Association·Andrea ViggianoGiangennaro Coppola
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Sep 4, 2014·Asian Pacific Journal of Tropical Biomedicine·Musa Mumammad AliyuMagaji Garba Mohammed
Apr 21, 2007·Annual Review of Nutrition·Marc YudkoffItzhak Nissim
Sep 12, 2007·Journal of Neuroscience Research·Mary C McKenna
Feb 28, 2008·Current Opinion in Clinical Nutrition and Metabolic Care·Do Young Kim, Jong M Rho
Mar 17, 2021·Seizure : the Journal of the British Epilepsy Association·Estela M BruxelIscia Lopes-Cendes

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