PMID: 9428933Jan 16, 1998Paper

Short-term healing kinetics of cortical and cancellous bone osteopenia induced by unloading during the reloading period in young rats

Virchows Archiv : an International Journal of Pathology
M WeinrebS Ben-Shemen

Abstract

We investigated the short-term recuperation of bone mass during skeletal reloading after a period of unloading in young rats. One hind limb of 4-week-old rats was either unloaded irreversibly by sciatic neurectomy, or unloaded reversibly by external fixation. Other animals were sham-operated. After 9 days, the fixation-unloaded limbs were reloaded for 1-3 weeks and were compared with the hind limbs of age-matched unloaded (neurectomized) and sham-operated controls. Cortical and cancellous bone mass was measured using ashing and histomorphometry. Cortical bone mass (expressed as femoral dry and ash weight and tibial cortical bone area) was reduced in both unloaded groups and was accompanied by production of hypomineralized bone, as shown by a reduction in the percent ash of the dry weight. Cancellous bone mass (expressed as bone area and surface at the tibial metaphysis) was also reduced in both unloaded groups. Cortical bone mass deficit was greater in the fixation group than in the neurectomy group. Thereafter it increased in the neurectomy group despite a normal longitudinal growth rate, but returned to age-matched values in the reloaded group by 3 weeks. The changes in tibial cancellous bone mass were more pronounced but fol...Continue Reading

Citations

Feb 6, 2007·The Journal of Hand Surgery, European Volume·E KekilliF Ceylan
Oct 10, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Meghan E McGee-LawrenceSeth W Donahue
May 25, 2010·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Linda SpiegelbergKarel G van der Wal
Oct 2, 2007·Journal of Ethnopharmacology·Sang Yeob HanSae Kwang Ku
Jun 21, 2006·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Ersoy KekilliFethi Ceylan
Jun 25, 2005·Journal of Biomechanics·Seth W DonahueCharles T Robbins
Jan 16, 2019·Annals of the New York Academy of Sciences·Dongye ZhangYi-Xian Qin
Jun 4, 2005·Phytotherapy Research : PTR·Bu Il SeoHyeung Sik Lee
Mar 5, 2003·Clinical Orthopaedics and Related Research·Seth W DonahueHenry J Donahue
Sep 3, 2016·Experimental and Therapeutic Medicine·Mi Young JungSae Kwang Ku
Aug 15, 2014·Experimental and Therapeutic Medicine·Jae-Suk ChoiSae Kwang Ku
Oct 29, 2003·The Journal of Experimental Biology·Seth W DonahueHenry J Donahue

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.