Short-term hypocaloric nutrition but not bed rest decrease insulin sensitivity and IGF-I bioavailability in healthy subjects: the importance of glucagon

Nutrition
J NygrenO Ljungqvist

Abstract

Hyperinsulinemic, normoglycemic clamps were performed before and after 24 h of either hypocaloric nutrition or bed rest in healthy subjects. Decreased insulin sensitivity and insulin-like growth factor-I (IGF-I) bioavalibility, as measured by the serum IGF-I/insulin-like growth factor binding protein-1 (IGFBP-1) ratio, was found after fasting, whereas no metabolic changes were found after bed rest. Glucagon seems to be a key regulator of IGFBP-1 after brief hypocaloric nutrition. Hypocaloric nutrition and immobilization may add to the catabolic response to surgery and other trauma. Presently, six healthy subjects were studied before and after a 24-h period of hypocaloric nutrition (200 kcal/24 h, fast) or immobilization (bed rest) using the hyperinsulinemic (0.8 mU.kg-1.min-1), normoglycemic (4.5 mmol/L) clamp, indirect calorimetry, and circulating levels of substrates and hormones. After fast, body weight decreased (P < 0.05), and nitrogen balance was negative (-10 +/- 1 g urea nitrogen/24 h). Basal levels of free fatty acids, glucagon, and IGFBP-1 increased (P < 0.05), whereas c-peptide levels and the IGF-I/IGFBP-1 ratio decreased (P < 0.05). However, no change was found in basal levels of IGF-1 or substrate oxidation. Furthe...Continue Reading

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Citations

Nov 9, 2011·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M LagerpuschM J Müller
Nov 1, 2000·Surgery·O LjungqvistA Thorell
Sep 17, 2002·The Proceedings of the Nutrition Society·Olle LjungqvistAnders Thorell
Aug 24, 1999·Current Opinion in Clinical Nutrition and Metabolic Care·A ThorellO Ljungqvist
Jul 8, 2010·Journal of Emergencies, Trauma, and Shock·Sabita JivnaniM A Gore
Jan 1, 2008·The Libyan Journal of Medicine·Ss Qader
Mar 5, 2013·Journal of Nutrition in Gerontology and Geriatrics·Annabel J McDonald
Nov 5, 2014·BMC Anesthesiology·Fatos SadaFloren Kavaja
Jan 30, 2010·Best Practice & Research. Clinical Anaesthesiology·Olle Ljungqvist
May 19, 2009·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Sherif AwadDileep N Lobo
Apr 2, 2015·Current Opinion in Anaesthesiology·Jonas NygrenOlle Ljungqvist
Mar 4, 2014·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Bayar BabanOlle Ljungqvist
Sep 30, 2014·PloS One·Giancarlo BilancioMassimo Cirillo
Aug 7, 2009·Experimental Biology and Medicine·Anne-Mari MustonenPetteri Nieminen
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Nov 4, 2006·Best Practice & Research. Clinical Anaesthesiology·Jonas Nygren

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