Short-term Increase in Risk of Overweight and Concomitant Systolic Blood Pressure Elevation in Treatment-Naïve Persons Starting INSTI-Based Antiretroviral Therapy

Open Forum Infectious Diseases
Ronald GaldamezMar Masiá

Abstract

Integrase strand transfer inhibitors (INSTI) have been associated with weight gain, but their effect on short-term overweight and obesity incidence, blood pressure (BP), and metabolic markers has not been described in treatment-naïve people with HIV(PWH). Medical records of treatment-naïve persons starting antiretroviral therapy (ART) at the HIV Clinic of University Hospital of Elche, Spain, between January 2007 and July 2019 were reviewed retrospectively. Standard procedures included measurements of weight, BP, and metabolic assessment. Data at baseline, 48, 72, and 96 weeks post ART initiation were analyzed. We used Cox mixed-effects model to generate predictions of body mass index (BMI) over time and generalized additive mixed models to relax the linearity assumptions and generate 95% confidence intervals in the multivariable adjustment. Among 219 (median age, 44.0 years; interquartile range [IQR], 37.0-53.5; 46 females) participants. Baseline weight mean (standard deviation) was 70.4 (13.7) kg without difference between regimens; 66% had a BMI <25 kg/mt2. The incidence of overweight and obesity was significantly greater in persons starting INSTI-based regimens: 15 (36.6%) of 41 patients treated with INSTI versus 30 (28.9%) ...Continue Reading

Citations

Oct 22, 2020·International Journal of STD & AIDS·Daniela PiacentiniSandro Vento
Feb 26, 2021·Journal of the International Association of Providers of AIDS Care·Rachel N GoldbergMelissa E Badowski

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