PMID: 6986533Feb 1, 1980Paper

Short-term influences of dichloroacetate on genetically hyperlipemic rats

Metabolism: Clinical and Experimental
A Hayek, W F Woodside

Abstract

The effects of short-term (7 days) administration of dichloroacetate (DCA) on carbohydrate and lipid metabolism in the Zucker obese and lean rat were investigated. Metabolic effects of the drug were more pronounced in the obese than in the lean rat. DCA decreased fasting blood glucose concentrations in both lean and obese rats, but more so in the fat animals, probably because of higher initial levels. The hypoglycemic action of DCA is likely attributable to a direct effect on liver and peripheral tissues and not to an indirect action caused by a decrease in the glucagon-to-insulin ratio because the drug induced just the opposite effect. DCA decreased plasma triglycerides (TG) and free fatty acids (FFA) in the hyperlipemic rats but not in lean rats. Intrahepatic triglyceride content diminished after drug treatment in fat rats, suggesting decreased hepatic TG synthesis. Hyperketonemia, induced in both lean and fat rats by DCA treatment, was also greater in the obese animal. This response was probably caused by accelerated hepatic ketone body production due to increased beta-oxidation, and not to enhance FFA substrate supply. These data demonstrate that DCA is capable of correcting many of the underlying abnormalities in carbohydr...Continue Reading

References

Feb 15, 1979·The New England Journal of Medicine·P W StacpooleD M Kornhauser
Aug 1, 1979·Metabolism: Clinical and Experimental·D S SchadeR P Eaton
Jan 1, 1979·Advances in Experimental Medicine and Biology·W F Woodside
Mar 9, 1978·The New England Journal of Medicine·P W StacpooleD M Kornhauser
Dec 1, 1978·Metabolism: Clinical and Experimental·W F Woodside, M Heimberg
Feb 1, 1979·Metabolism: Clinical and Experimental·J TriscariA C Sullivan
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May 1, 1976·The American Journal of Physiology·R P EatonD S Schade
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Sep 1, 1962·Biochemical Pharmacology·M LORINI, M CIMAN

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Citations

May 1, 1993·Pflügers Archiv : European journal of physiology·B LudvikH Graf
Nov 1, 1986·Environmental Health Perspectives·M J ParnellJ M Arnzen
Mar 1, 1982·Metabolism: Clinical and Experimental·J TriscariA C Sullivan
Dec 1, 1985·The Journal of Pharmacy and Pharmacology·A R RenzettiA Subissi
Oct 1, 1981·Metabolism: Clinical and Experimental·D W CrabbR A Harris
Nov 1, 1989·Metabolism: Clinical and Experimental·P W Stacpoole

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