PMID: 2112625Mar 1, 1990Paper

Short-term infusion of azelaic acid vs intralipid in healthy subjects evaluated by indirect calorimetry

JPEN. Journal of Parenteral and Enteral Nutrition
R M TacchinoM Castagneto

Abstract

Medium-chain dicarboxylic acids (MCDA) are usually considered byproducts of beta-oxidation when omega-oxidizable medium-chain monocarboxylic acids are accumulated, as in beta-oxidation impairment. However, evidence exists of a mitochondrial and cytoplasmatic peroxisomal carnitine independent beta-oxidation of these diacids. Our purpose was to evaluate whether MCDA could be used as source of calories. The metabolic response to intravenous administration of azelaic acid (AA) vs Intralipid (IL) was evaluated in six healthy overnight fasting male volunteers who received an infusion of 10 g of AA over 80 min and as a control 10 g of IL. AA reached a peak concentration at 80 min, (589 +/- 61 micrograms/ml) and was rapidly cleared from plasma (82 +/- 5 micrograms/ml at 240 min). Respiratory and metabolic parameters were evaluated by indirect calorimetry from the beginning of the infusion for 240 min. In both groups the CO2 production (VCO2) remained unchanged with no significant change from basal values. The O2 consumption (VO2 ml/min/m2) increased over basal values reaching a peak at the end of the infusion in both groups (AA from 119.4 +/- 16.9 to 143.0 +/- 27.6; IL from 124.7 +/- 16.8 to 152.3 +/- 29.5). Respiratory quotient (RQ) c...Continue Reading

Citations

Jun 1, 1992·Irish Journal of Medical Science·D J Hehir, T F Gorey
Feb 17, 1997·Clinica Chimica Acta; International Journal of Clinical Chemistry·A V GrecoF Nervi
Mar 26, 2015·Biochemical and Biophysical Research Communications·NaNa KangJaeHyung Koo
May 1, 1994·JPEN. Journal of Parenteral and Enteral Nutrition·G MingroneM Castagneto
Jan 1, 1996·JPEN. Journal of Parenteral and Enteral Nutrition·G MingroneG Gasbarrini
Nov 1, 1995·JPEN. Journal of Parenteral and Enteral Nutrition·A BertuzziS Salinari
Mar 19, 1999·JPEN. Journal of Parenteral and Enteral Nutrition·G MingroneG Gasbarrini
Jul 1, 1991·JPEN. Journal of Parenteral and Enteral Nutrition·G MingroneM Castagneto
Jun 24, 2005·American Journal of Physiology. Endocrinology and Metabolism·Simona PanunziGeltrude Mingrone
Mar 10, 1999·The American Journal of Physiology·A de GaetanoG Gasbarrini
Jun 1, 1995·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·A V Grego, G Mingrone

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