Short-Term, Intermittent Fasting Induces Long-Lasting Gut Health and TOR-Independent Lifespan Extension

Current Biology : CB
James H CattersonLinda Partridge

Abstract

Intermittent fasting (IF) can improve function and health during aging in laboratory model organisms, but the mechanisms at work await elucidation. We subjected fruit flies (Drosophila melanogaster) to varying degrees of IF and found that just one month of a 2-day fed:5-day fasted IF regime at the beginning of adulthood was sufficient to extend lifespan. This long-lasting, beneficial effect of early IF was not due to reduced fecundity. Starvation resistance and resistance to oxidative and xenobiotic stress were increased after IF. Early-life IF also led to higher lipid content in 60-day-old flies, a potential explanation for increased longevity. Guts of flies 40 days post-IF showed a significant reduction in age-related pathologies and improved gut barrier function. Improved gut health was also associated with reduced relative bacterial abundance. Early IF thus induced profound long-term changes. Pharmacological and genetic epistasis analysis showed that IF acted independently of the TOR pathway because rapamycin and IF acted additively to extend lifespan, and global expression of a constitutively active S6K did not attenuate the IF-induced lifespan extension. We conclude that short-term IF during early life can induce long-las...Continue Reading

Citations

Jun 4, 2019·International Ophthalmology·Brian K ArmstrongSamuel Navon
Jun 23, 2020·EMBO Reports·Maja C FunkMichael Boutros
Mar 16, 2019·International Journal of Molecular Sciences·Anna Bielak-ZmijewskaEwa Sikora
Oct 22, 2019·Critical Reviews in Food Science and Nutrition·Cem Ekmekcioglu
Aug 24, 2018·International Journal of Molecular Sciences·Kyung-Jin Min, Marc Tatar
Jul 19, 2019·Nutrients·Ronald D HillsCory R Theberge
Aug 4, 2019·Biogerontology·Sudhakar Krittika, Pankaj Yadav
Nov 8, 2020·Communications Biology·Nicole L Stuhr, Sean P Curran
Dec 29, 2020·Current Opinion in Biotechnology·Steven N Austad, Jessica M Hoffman
Aug 22, 2020·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Claudia CantoniLaura Piccio
Nov 17, 2020·Frontiers in Genetics·Shaza AsifKyoung-Han Kim
Jan 12, 2021·Frontiers in Aging Neuroscience·Mitchell Thelen, Holly M Brown-Borg
May 19, 2021·Nature Communications·Victoria A Acosta-RodríguezJoseph S Takahashi
Dec 24, 2018·Aging and Disease·Ashok K ShettyLeelavathi N Madhu
Jul 30, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Fan YangYanwei Xing
Sep 23, 2021·Journal of Biological Rhythms·Yool LeeAmita Sehgal
Oct 1, 2021·Nature·Matt UlgheraitMimi Shirasu-Hiza

❮ Previous
Next ❯

Methods Mentioned

BETA
protein assay
PCR

Key Resources (RRID) Mentioned

BDSC_3605
BDSC_6914
BDSC_55850
BDSC_1309

Software Mentioned

Prism
ImageJ
Adobe
GraphPad
R
R Core Team
GraphPad Prism
Adobe Illustrator
R statistics package
Excel

Related Concepts

Related Feeds

Cell Aging (Keystone)

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Related Papers

Biochemical Society Transactions
Ivana Bjedov, Linda Partridge
Evidence-based Complementary and Alternative Medicine : ECAM
Hsin-Ping LiuFuu-Jen Tsai
Pharmacological Research : the Official Journal of the Italian Pharmacological Society
Ekaterina LashmanovaA A Moskalev
© 2022 Meta ULC. All rights reserved