Short-term itraconazole versus terbinafine in the treatment of tinea pedis or manus

International Journal of Dermatology
I TauschA Del Palacio

Abstract

A total of 304 patients with a clinical diagnosis of palmar-type tinea pedis or manus and a positive mycologic examination were recruited into this double-blind, randomized, multicenter, phase III study. Patients were randomized to receive either oral itraconazole 200 mg twice daily (in the morning and evening) for 7 days, followed by placebo for 7 days (n = 153), or placebo in the morning and oral terbinafine 250 mg in the evening for 14 days (n = 151). At the first visit and 1, 2, and 6 weeks after the start of the study, signs and symptoms were assessed clinically, and scales were taken for mycologic assessments (microscopy and culture). At weeks 1, 2, and 6, the effectiveness of therapy was evaluated globally and given a rating of healed (absence of signs and symptoms), marked improvement (> or = 50% clinical improvement), considerable residual lesions (< 50% clinical improvement), no change, or worsened. The primary efficacy parameter was the mycologic cure rate at the follow-up end-point (week 6). The tolerability of the study medications was assessed at weeks 1 and 2. Adverse events were recorded at weeks 1, 2, and 6. Routine hematologic and biochemical tests were performed at the start of the study and after 1 week of t...Continue Reading

Citations

Aug 12, 2000·International Journal of Dermatology·A K GuptaH Degreef
Jul 18, 2002·The Australasian Journal of Dermatology·Andrew C SatchellRoss St C Barnetson
Apr 14, 2007·Dermatologic Clinics·Alexandra Y ZhangBoni E Elewski
Jan 31, 2006·Journal of the European Academy of Dermatology and Venereology : JEADV·S MistikA Ozturk
Sep 4, 2007·The American Journal of Medicine·Chia-Hsuin ChangArnold K Chan
Sep 6, 2003·Dermatologic Clinics·Aditya K GuptaRaza Aly
Aug 19, 2005·Expert Review of Anti-infective Therapy·Adolfo C Fernandez-ObregonCarolyn Willis
May 18, 2000·Primary Care·S J Rupke
Feb 24, 2001·Drugs·J F Meis, P E Verweij
Nov 24, 2018·Journal of Medical Ethics·Rosalind J McDougall
Oct 19, 2012·The Cochrane Database of Systematic Reviews·Sally E M Bell-SyerDavid J Torgerson
Jul 27, 2001·Postgraduate Medicine·D Berg, P Erickson
Aug 10, 2016·Mycopathologia·Aditya K GuptaSarah G Versteeg

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