PMID: 15248820Jul 14, 2004Paper

Short-term low-dose growth hormone administration in subjects with impaired glucose tolerance and the metabolic syndrome: effects on beta-cell function and post-load glucose tolerance

European Journal of Endocrinology
K C J YuenD B Dunger

Abstract

Modest elevations in circulating IGF-I levels have been suggested to protect against the development of glucose intolerance in insulin-resistant subjects. To further understand the interactions of GH and IGF-I on beta-cell function and post-load glucose tolerance in glucose-intolerant subjects predisposed to diabetes, we performed a pilot study in 12 subjects with impaired glucose tolerance and the metabolic syndrome using a low GH dose (1.7 microg/kg per day) known to increase endogenous IGF-I production. Fourteen daily GH or placebo injections in a double-blind cross-over study. Baseline and post-treatment oral glucose tolerance tests were performed. The homeostasis model assessment and the insulinogenic index was used to estimate fasting insulin sensitivity (S(I)) and beta-cell function respectively, whereas changes in the incremental area under the curve were used to estimate post-load glucose tolerance (DeltaAUC(glu)) and post-load insulin levels (DeltaAUC(ins)). GH increased total IGF-I (P<0.02), free IGF-I (P<0.04) and fasting insulin (P<0.04) levels, but did not modify plasma IGF-binding proteins (IGFBPs)-1 and -3, fasting glucose, non-esterified fatty acid and C-peptide levels, and fasting S(I). After oral glucose inta...Continue Reading

Citations

Nov 23, 2011·Metabolic Syndrome and Related Disorders·Abayomi O Akanji, Robert J Smith
Jul 16, 2009·The Journal of Clinical Endocrinology and Metabolism·Thomas MünzerMarc R Blackman
Mar 18, 2011·Medicina clínica·Daniel CaboJordi Mesa
Apr 21, 2006·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Kevin C J Yuen, David B Dunger
Jan 20, 2012·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Zhi Xin ZhangChun He
Jul 28, 2005·American Journal of Physiology. Endocrinology and Metabolism·Mette HansenKai Henrik Wiborg Lange
Sep 6, 2007·The Journal of Clinical Endocrinology and Metabolism·Magdalena PasaricaSteven R Smith
Jul 20, 2007·The Proceedings of the Nutrition Society·D B DungerK K Ong
May 15, 2008·Hormones : International Journal of Endocrinology and Metabolism·Roberta GiordanoEmanuela Arvat

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