Short-Term Omega 3 Fatty Acids Treatment for Dry Eye in Young and Middle-Aged Visual Display Terminal Users

Eye & Contact Lens
Rahul BhargavaYogesh Arora

Abstract

To evaluate the effect of an omega 3 fatty acid (O3FA) oral supplement (2,400 mg/day) for 45 days on dry eye symptoms, tear production, stability, and conjunctival cytology in young and middle-aged visual display terminal (VDT) users. Institutional review board approval was obtained, and a randomized, double-blind, interventional study was done; eyes of 256 VDT users were randomized to receive 4 capsules twice daily for 45 days (O3FA group), each containing 180 mg of eicosapentaenoic acid and 120 mg docosahexaenoic acid. The O3FA group was compared with another group (n=266) who received 8 capsules of a placebo (olive oil). Patients were evaluated at baseline, 30 days, and 45 days. The primary outcome measure was an improvement in dry eye symptoms. Secondary outcome measures were improvement in the Nelson grade on conjunctival impression cytology, Schirmer test values, and tear film breakup time (TBUT). Means of groups (pretreatment, day 30, and day 45) were compared with repeated-measure analysis of variance. The relation between the outcome variables and VDT time was evaluated using linear regression. In the O3FA group, the mean symptom score differed significantly (P<0.005) (pretreatment, 30 days, and 45 days); the TBUT and ...Continue Reading

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Citations

Jul 23, 2016·Indoor Air·P Wolkoff
Dec 18, 2019·The Cochrane Database of Systematic Reviews·Laura E DownieEsen K Akpek
Apr 3, 2020·Nutrients·Marco PellegriniGiuseppe Giannaccare
May 26, 2018·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Chantal Coles-BrennanGraeme Young
Oct 15, 2020·The Ocular Surface·Cristian Talens-EstarellesSantiago García-Lázaro

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