Short term omega-3 polyunsaturated fatty acid supplementation induces favorable changes in right ventricle function and diastolic filling pressure in patients with chronic heart failure; A randomized clinical trial

Vascular Pharmacology
Christina ChrysohoouDimitris Tousoulis

Abstract

Omega-3 polyunsaturated fatty acids (omega 3-PUFAs) seem to favorably affect cardiac hemodynamics and may benefit the clinical course of heart failure patients. The role of omega 3-PUFAs supplementation on the left and right ventricular function of patients with chronic compensated systolic heart failure, under optimal treatment, was studied. 205 consecutive patients with chronic compensated heart failure, due to ischemic (IHF) or dilated cardiomyopathy (DCM)-NYHA classification I-III, under optimal medical treatment, were enrolled. Participants were 1-to-1 randomized on 1000 mg omega 3-PUFA supplementation or no supplementation, in a non-blinded fashion. Echocardiographic assessment was performed at first visit and 6 months after. Plasma BNP and serum creatinine levels were also measured. As compared with the control group, BNP levels in omega 3-PUFA intervention group were 34.6% lower (p=0.001); end-diastolic and end-systolic left ventricle dimensions were decreased by 2.5% (p=0.047) and 3.7% (p=0.01), maximum diameter of left atrium was decreased by 8.4% (p=0.004), left atrium ejection fraction was ameliorated by 6.03% (p=0.021) and as regards tissue Doppler parameters, TDI_Etv/Atv was decreased in omega 3-PUFA intervention ...Continue Reading

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Citations

Dec 18, 2016·Journal of Molecular and Cellular Cardiology·Timothy D O'ConnellGregory C Shearer
Jan 26, 2018·Journal of Cardiovascular Development and Disease·Marco Luciani, Federica Del Monte
Aug 21, 2019·International Journal of Molecular Sciences·Atsushi SakamotoYuichiro Maekawa
Mar 17, 2020·Nutrition Research Reviews·Arrigo F G CiceroUNKNOWN International Lipid Expert Panel
Jun 11, 2017·Nutrition Journal·Paula Simplício da SilvaAndrea Silvestre de Sousa
Aug 29, 2021·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Katharina LechnerFrank Edelmann

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