Short-term outcome and quality of life in kidney transplant recipient with monoclonal gammopathy

CEN Case Reports
Masaaki YanishiTadashi Matsuda

Abstract

Monoclonal gammopathy of undetermined significance (MGUS) is the common pre-malignant B cell disorders with a general prevalence of 3-5 % at age over 50. Because of the potential malignant transformation and immune insufficiency, pre-transplant MGUS recipient should be carefully followed after allograft transplantation. The post-transplant prognosis and quality of life (QOL) in patient with MGUS have not yet been fully determined. The aim of this study is to evaluate function and pathology of the renal allograft and self-assessment QOL changes during 2 years after transplantation in our case of MGUS-bearing recipient. We here studied the clinical course and QOL improvement before and 20 months after transplant in a 56-year-old woman, who had pre-existing MGUS and underwent living donor kidney transplantation. After the renal allograft transplant, the patients maintained normal GFR and had neither acute rejections nor histologic evidence of renal injuries related to the monoclonal gammopathy on the protocol biopsy of 1 year post-transplant. During further 20 months follow-up, the pre-transplant MGUS remained uneventful without any hematologic abnormalities and other medical complications, i.e., infection. Evaluation of QOL using...Continue Reading

References

Sep 1, 1982·Kidney International·J P JohnsonJ B Copley
Aug 18, 2001·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·J GreenK Kurokawa
Feb 22, 2002·The New England Journal of Medicine·Robert A KyleL Joseph Melton
Sep 16, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Stefan VítkoUNKNOWN RAD B201 Study Group
Mar 31, 2006·The New England Journal of Medicine·Robert A KyleL Joseph Melton
Apr 13, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·K A AndreoniR S Sung
Nov 3, 2011·Clinical Transplantation·Liliana SolteroHoracio E Adrogué
Jan 22, 2015·Kidney International·Frank BridouxUNKNOWN International Kidney and Monoclonal Gammopathy Research Group

❮ Previous
Next ❯

Related Concepts

Related Feeds

B-Cell Leukemia (Keystone)

B-cell leukemia includes various types of lymphoid leukemia that affect B cells. Here is the latest research on B-cell leukemia.

© 2022 Meta ULC. All rights reserved