Short-term outcome of kidney transplants from non-heart-beating donors after preservation by machine perfusion

Transplant International : Official Journal of the European Society for Organ Transplantation
J W DaemenG Kootstra

Abstract

In this study, the short-term outcome of renal transplants from non-heart-beating donors (NHBD) preserved by machine perfusion (MP) is evaluated and compared to preservation by cold storage (CS). Twenty-two NHBD kidneys were procured during 1993 and 1994 after in situ perfusion with histidine-tryptophan ketoglutarate and preserved by continuous perfusion using University of Wisconsin organ preservation solution for MP as a perfusate. Between 1980 and 1992, 57 NHBD kidneys were procured and preserved by CS. Donors in the MP group sustained increased first warm ischemia times (WIT1) (P < 0.1) and recipients in the MP group suffered longer anastomosis time, worse HLA-DR mismatch, and more initial use of cyclosporin as immunosuppressant; all these factors are known to be deleterious to short-term outcome. Despite these unfavorable conditions, delayed function (DF) rate was decreased in the MP group, although not significantly. However, when considering only kidneys with WIT1 > or = 45 min, short-term outcome was significantly better in the MP group (P < 0.05). We conclude that MP is superior for the preservation of NHBD kidneys, especially after prolonged warm ischemia.

References

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Citations

Feb 18, 2005·Transplant International : Official Journal of the European Society for Organ Transplantation·Thomas MinorFrank Dombrowski
Mar 2, 2005·Annales Françaises D'anesthèsie Et De Rèanimation·P Eschwège
Nov 26, 2003·Clinica Chimica Acta; International Journal of Clinical Chemistry·Muhammed A GokDavid Talbot
Jul 25, 2007·Journal of Gastroenterology and Hepatology·Hongzhi XuJian X Zhang
Jan 23, 2010·The British Journal of Surgery·M C J M SchreinemachersT M van Gulik
Jul 28, 2009·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Marcelo CypelAndrew Pierre

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