Short-term overfeeding induces insulin resistance in weight-stable patients after bariatric surgery

Obesity Surgery
Jeroen NijhuisJan Willem M Greve

Abstract

Short time overfeeding of rats rapidly leads to insulin resistance (IR). A study with healthy human volunteers, which we suggest are less susceptible for developing IR after short time overfeeding, did not show these effects on IR. Therefore a study population of weight-stable, former morbidly obese subjects (BMI 31.3 kg/m2), which were treated with bariatric surgery approximately 3 years ago was selected. Eleven subjects were submitted to a 7-day overfeeding study, resulting in a 53% increase in caloric intake (1,227 +/- 394.4 to 1,879.2 +/- 298.4 kcal/day). During normal diet and after overfeeding, insulin sensitivity was measured using steady state plasma glucose (SSPG) levels. At these time points, BMI and waist/hip ratio together with plasma levels of inflammatory markers (CRP, AGP, LBP, and TNF-alpha receptors) and plasma leptin values were also measured. SSPG levels after overfeeding increased from 8.2 +/- 3.2 to 10.6 +/- 2.6 mmol/l (P < 0.05), indicating decreased insulin sensitivity after overfeeding. Fasting plasma insulin, glucose, circulating levels of inflammatory markers, BMI, and waist/hip ratio remained unchanged. This study shows that overfeeding in a group of weight-stable, former morbidly obese subjects 3 yea...Continue Reading

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Citations

Jan 26, 2010·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Francois M H van DielenJan Willem M Greve
Aug 14, 2012·Gastroenterology·David BradleySamuel Klein
May 10, 2016·The Journal of Clinical Endocrinology and Metabolism·George A BraySteven R Smith
Jun 10, 2020·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·George A Bray, Claude Bouchard

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