Short-term peripheral nerve stimulation ameliorates axonal dysfunction after spinal cord injury

Journal of Neurophysiology
Michael LeeCindy S-Y Lin

Abstract

There is accumulating evidence that peripheral motor axons deteriorate following spinal cord injury (SCI). Secondary axonal dysfunction can exacerbate muscle atrophy, contribute to peripheral neuropathies and neuropathic pain, and lead to further functional impairment. In an attempt to ameliorate the adverse downstream effects that developed following SCI, we investigated the effects of a short-term peripheral nerve stimulation (PNS) program on motor axonal excitability in 22 SCI patients. Axonal excitability studies were undertaken in the median and common peroneal nerves (CPN) bilaterally before and after a 6-wk unilateral PNS program. PNS was delivered percutaneously over the median nerve at the wrist and CPN around the fibular head, and the compound muscle action potential (CMAP) from the abductor pollicis brevis and tibialis anterior was recorded. Stimulus intensity was above motor threshold, and pulses (450 μs) were delivered at 100 Hz with a 2-s on/off cycle for 30 min 5 days/wk. SCI patients had consistently high thresholds with a reduced CMAP consistent with axonal loss; in some patients the peripheral nerves were completely inexcitable. Nerve excitability studies revealed profound changes in membrane potential, with a...Continue Reading

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Citations

Dec 25, 2015·Journal of Physiotherapy·Lisa A Harvey
Mar 25, 2016·Journal of Physiotherapy·Lisa A HarveyUNKNOWN Spinal Cord Injury Physical Activity (SCIPA) Hands On Trial Collaborators
Jun 20, 2015·Frontiers in Human Neuroscience·Cliff S KleinChristina Marciniak
May 18, 2016·Surgery·Sergio CanaveroEdoardo Rosati
Oct 24, 2018·Proceedings of the National Academy of Sciences of the United States of America·Yi-Hung ChenLih-Chu Chiou
Jan 13, 2021·Interactive Cardiovascular and Thoracic Surgery·Matthew R KaufmanReza Jarrahy
May 27, 2021·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Chaojun ZhengJianyuan Jiang

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