Short-term postoperative outcomes of colorectal cancer among patients with chronic liver disease: a national population-based study

BMJ Open
Ko-Chao LeeChien-Chang Lu

Abstract

Patients with colorectal carcinoma (CRC) with pre-existing chronic liver disease (CLD) had a significantly higher 30-day mortality after CRC surgery compared with healthy controls. This study investigated the factors associated with postoperative complications and in-hospital mortality in patients with CRC with coexisting CLD (excluding cirrhosis) who underwent colorectal surgery. A retrospective, observational, population-based study. Data were sourced from the National Inpatient Sample database, a part of the Healthcare Cost and Utilisation Project. This study analysed 7463 inpatients with CRC who underwent colorectal surgery on admission between 2005 and 2014. The primary endpoint of this study was the prevalence of postoperative complications, and the secondary endpoint was in-hospital mortality. In the CLD group, 36.27% of patients had chronic hepatitis C, 28.36% had non-alcoholic fatty liver disease and 31.19% had other types of CLD. The median hospital stay was 7.0 (5.0-10.0) days in patients with no postoperative complications vs 17.0 (10.0-26.0) days, 8.0 (6.0-12.0) days, 8.0 (6.0-17.0) days, 9.0 (8.0-14.0) days and 10.5 (7.0-17.0) days for patients with postoperative infection, postoperative bleeding, cardiac arrest/h...Continue Reading

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