Abstract
Quantification of short-term progression of active neovascular age-related macular degeneration and correlation with 1-year outcome. Sixty-five patients with newly diagnosed treatment-naive active subfoveal choroidal neovascularization (CNV), who had participated in clinical trials testing anti-vascular endothelial growth factor therapy, were retrospectively assessed. Early Treatment Diabetic Retinopathy Study best-corrected visual acuity (BCVA), Spectral Domain Optical Coherence Tomography (SD-OCT) and fluorescein angiography (FA) were performed twice during the pretreatment period. Changes in BCVA, central retinal thickness (CRT), average macular thickness (AMT) and leakage area were documented within this pretreatment period for all patients and for lesion type I (occult CNV, n=42) and type II (classic CNV, n=23). Three-month and 1-year BCVA were then correlated with the pretreatment period. The pretreatment period was 19±3 days (range: 2-108). Neither type I nor type II lesions showed a significant BCVA decrease or CRT/AMT increase during this period. On FA, mean leakage area increased significantly during the pretreatment period: in the pooled group from 5.50±0.62 (screening) to 7.60±0.86 mm2 (baseline) (p<0.0001), in type...Continue Reading
References
Jul 1, 1982·American Journal of Ophthalmology·F L FerrisI Bailey
Feb 1, 1995·Ophthalmology·J R VingerlingP T de Jong
Oct 1, 1996·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·U SchneiderI Kreissig
Jan 1, 1997·Ophthalmology·R KleinS M Meuer
Jul 14, 2001·Eye·M Votruba, Z Gregor
Sep 10, 2003·Archives of Ophthalmology·Irene BarbazettoUNKNOWN Verteporfin in Photodynamic Therapy Study Group
Mar 17, 2004·Ophthalmology·Timothy W OlsenEric R Steuer
May 12, 2004·Archives of Ophthalmology·Farrukh AliUsha Chakravarthy
Dec 13, 2005·Retina·Daniel Pauleikhoff
Mar 21, 2006·Issues in Emerging Health Technologies·D Maberley
Oct 6, 2006·The New England Journal of Medicine·Philip J RosenfeldUNKNOWN MARINA Study Group
Dec 26, 2006·American Journal of Ophthalmology·Ankoor R Shah, Lucian V Del Priore
Jan 3, 2007·Ophthalmology·Jie Jin WangPaul Mitchell
Feb 3, 2007·Ophthalmology·David S BoyerUNKNOWN MARINA Study Group
May 22, 2007·Progress in Retinal and Eye Research·Ursula M Schmidt-Erfurth, Christian Pruente
Aug 7, 2007·Ophthalmology·Tien Y WongIsabella Sledge
Oct 24, 2007·American Journal of Ophthalmology·Peter K KaiserNisha R Acharya
Jun 14, 2008·The New England Journal of Medicine·Rama D JagerJoan W Miller
Oct 17, 2008·The New England Journal of Medicine·Daniel Seigel
Nov 26, 2008·Lancet·Hanna R ColemanEmily Y Chew
Dec 18, 2008·Japanese Journal of Ophthalmology·Sebastian Wolf
Mar 6, 2009·Retina·Mi In RohOh Woong Kwon
May 16, 2009·The British Journal of Ophthalmology·P MitchellS Wolf
Jun 12, 2009·Retina·Francesco ViolaGiovanni Staurenghi
Jul 14, 2009·Ophthalmology·Ankoor R Shah, Lucian V Del Priore
Feb 19, 2010·Acta Ophthalmologica·Yasuo TanoUNKNOWN EXTEND-I Study Group
Oct 6, 2010·Ophthalmology·Philip J RosenfeldUNKNOWN MARINA and ANCHOR Study Groups
Jan 15, 2011·Acta Ophthalmologica·Yasuo TanoUNKNOWN EXTEND-I Study Group