Short-term repeat cognitive testing and its relationship to hippocampal volumes in older adults

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
Kevin DuffJohn M Hoffman

Abstract

Practice effects are improvements in cognitive test scores due to repeated exposure to testing materials. If practice effects provide information about Alzheimer's disease pathology, then they could be useful for clinical trials enrichment. The current study sought to add to the limited literature on short-term practice effects on cognitive tests and their relationship to neuroimaging biomarkers. Twenty-five, non-demented older adults (8 cognitively intact, 17 with mild cognitive impairment) received magnetic resonance imaging and two testing sessions across one week to determine practice effects on seven neuropsychological test scores. A series of correlations examined if hippocampal volume was associated with baseline, one-week, or practice effects scores on these tests. Next, a series of stepwise multiple regression models examined which of the three test scores best predicted hippocampal volumes RESULTS: In the correlation analysis, baseline scores on 5 of the 7 tests were significantly associated with hippocampal volumes, one week scores were significantly related for 7 of the 7 tests, and practice effects scores were significantly correlated for 4 of the 7 tests. In the stepwise regression models, 5 of the 7 tests indicat...Continue Reading

Citations

Nov 17, 2019·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Dustin B Hammers, Kevin Duff
Feb 7, 2020·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Dustin B HammersKevin Duff
Jul 1, 2020·The Clinical Neuropsychologist·Kevin Duff, Dustin B Hammers
Jul 24, 2020·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Kevin Duff
Jul 17, 2020·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Roos J JuttenLaura A Rabin
Sep 5, 2020·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Dustin B HammersKevin Duff
Jul 3, 2020·Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition·Dustin B HammersKevin Duff
May 7, 2021·Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition·Dustin B HammersJohn M Hoffman
Sep 3, 2021·Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology·Dustin B HammersRobert J Spencer

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