Abstract
Magnetic resonance elastography (MRE) can estimate liver stiffness (LS) noninvasively. We prospectively assessed whether motion-encoding gradient (MEG) direction, slice position, or high-caloric food intake affects the repeatability of MRE measurements of LS. Twenty healthy volunteers (8 women, 12 men; age, 48 ± 12 years) were imaged in a 3.0T scanner at four timepoints: twice after overnight fasting (B1 , B2 ) and twice after consuming a 1050-calorie standardized meal (A1 , A2 ; after 30 and 60 min, respectively). Each session comprised sequential MRE acquisitions in which MEG was applied in three orthogonal directions with three slices positioned over the liver for each. Between sessions, the participants were repositioned to assess test-retest reproducibility. The LS measurements before/after food intake were 3.36 ± 1.31 kPa/3.22 ± 1.03 kPa, 2.04 ± 0.33 kPa/2.27 ± 0.38 kPa, and 2.47 ± 0.50 kPa/2.64 ± 0.76 kPa for MEG superimposed along the anterior-posterior (AP), foot-head (FH), and right-left (RL) directions, respectively. Before and after food intake, LS estimates were lower and more reproducible (<10% coefficient of variation) when the MEG was in the FH direction, not the AP or RL direction. Liver stiffness estimates wer...Continue Reading
References
Sep 29, 1995·Science·R MuthupillaiR L Ehman
Jan 1, 1994·European Journal of Applied Physiology and Occupational Physiology·M DauzatG Pomier-Layrargues
Dec 4, 2001·Medical Image Analysis·A ManducaR L Ehman
Oct 19, 2002·The American Journal of Gastroenterology·Arie RegevEugene R Schiff
Dec 31, 2003·Ultrasound in Medicine & Biology·Laurent SandrinRobert Palau
Feb 4, 2005·The Journal of Clinical Investigation·Ramón Bataller, David A Brenner
Feb 11, 2005·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Don C Rockey
Mar 8, 2006·NMR in Biomedicine·Laurent HuwartBernard E Van Beers
Oct 6, 2007·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Meng YinRichard L Ehman
Oct 18, 2007·Radiology·Laurent HuwartBernard E Van Beers
Mar 13, 2008·Journal of Hepatology·Laurent CasteraAlfredo Alberti
Jun 19, 2009·The American Journal of Clinical Nutrition·Kiran D K AhujaMadeleine J Ball
Sep 8, 2009·Liver International : Official Journal of the International Association for the Study of the Liver·Ingmar MederackeMatthias J Bahr
Feb 27, 2010·Journal of Magnetic Resonance Imaging : JMRI·Catherine D G HinesScott B Reeder
Aug 5, 2010·Cleveland Clinic Journal of Medicine·Emily Carey, William D Carey
Dec 25, 2010·Journal of Magnetic Resonance Imaging : JMRI·Catherine D G HinesScott B Reeder
Jun 28, 2011·AJR. American Journal of Roentgenology·Meng YinRichard L Ehman
Sep 1, 2011·European Radiology·Bang-Bin ChenTiffany Ting-Fang Shih
Apr 28, 2012·Gastroenterology·Hashem B El-Serag
Jan 3, 2013·Journal of Magnetic Resonance Imaging : JMRI·Dong Ho LeeByung Ihn Choi
Jan 3, 2013·Journal of Magnetic Resonance Imaging : JMRI·Bogdan DzyubakRichard L Ehman
Feb 19, 2013·Ultrasound in Medicine & Biology·Alina PopescuCristian Ivascu Siegfried
Feb 21, 2013·Journal of Magnetic Resonance Imaging : JMRI·Sudhakar K VenkateshRichard L Ehman
Mar 1, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Umberto ArenaMassimo Pinzani
Dec 7, 2013·Alimentary Pharmacology & Therapeutics·M LemoineM Thursz
Mar 22, 2014·Magnetic Resonance Imaging·Yu ShiYuying Gao
May 21, 2014·PloS One·Guido H JajamovichBachir Taouli
Aug 5, 2014·Magnetic Resonance Imaging Clinics of North America·Sudhakar Kundapur Venkatesh, Richard L Ehman
Oct 12, 2014·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Siddharth SinghRichard L Ehman
Citations
Jun 11, 2016·Radiology·Andrew T TroutJonathan R Dillman
May 23, 2017·Radiology·Suraj D SeraiRichard L Ehman
Oct 6, 2017·Physics in Medicine and Biology·Jin Long YueXavier Maître
Aug 28, 2019·Journal of Magnetic Resonance Imaging : JMRI·Mary Catherine SawhJeffrey B Schwimmer
Sep 17, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Hui WangCharles L Dumoulin
Jul 30, 2021·Clinics and Research in Hepatology and Gastroenterology·Jérôme BoursierVictor de Lédinghen