Short term results of complete (D3) vs. standard (D2) mesenteric excision in colon cancer shows improved outcome of complete mesenteric excision in patients with TNM stages I-II

Techniques in Coloproctology
K E StorliGeir Egil Eide

Abstract

The aim of the present study was to investigate whether the new method of complete mesocolic excision (CME) with a high (apical) vascular tie (D3 resection) had an immediate effect compared with a conventional (standard) approach even in those patients without lymph node metastases. A cohort of 189 consecutive patients with tumour-nodal-metastasis (TNM) stages I-II and a mean age of 73 years were operated on in the period from January 2007 to December 2008 in three community teaching hospitals. The CME approach (n = 89), used in hospital A, was compared to the standard technique used (n = 105) in two other hospitals, B and C. Lymph node yields from the specimens were used as a surrogate measure of radical resections. Outcome was analysed after a median follow-up of 50.2 months. In-hospital mortality rate was 2.8 % in the CME group and 8.6 % in the standard group. The 3-year overall survival (OS) in the CME group was 88.1 versus 79.0 % (p = 0.003) in the standard group, and the corresponding disease-free survival (DFS) was 82.1 versus 74.3 % (p = 0.026). Cancer-specific survival was 95.2 % in the CME group versus 90.5 % in the standard group (p = 0.067). Age, operative technique, and T category were significant in multiple Cox r...Continue Reading

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Citations

Mar 7, 2014·Techniques in Coloproctology·R Sehgal, J C Coffey
Jul 6, 2014·Techniques in Coloproctology·L Stocchi
Jul 30, 2016·International Journal of Colorectal Disease·Nikolaos GouvasEvaghelos Xynos
Feb 21, 2016·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·F OlofssonI Syk
Oct 27, 2017·Journal of Robotic Surgery·Scott R KelleyDavid W Larson
Dec 12, 2017·World Journal of Gastrointestinal Surgery·Kristian Eeg StorliGeir Egil Eide
Jun 28, 2018·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·C A BertelsenK J Emmertsen
Sep 28, 2017·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·C WangY Ye
Jul 4, 2020·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·J GoriA Saklani
Dec 13, 2016·Annals of Surgical Oncology·Ian M PaquetteGeorge J Chang
Aug 31, 2018·Updates in Surgery·Giuseppe SpinoglioWanda Petz
Nov 16, 2018·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Corrado PedrazzaniAlfredo Guglielmi
Mar 1, 2020·International Journal of Colorectal Disease·Kheng-Seong NgDavid G Jayne
May 18, 2016·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·Christos AthanasiouDanilo Miskovic
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Jan 13, 2015·World Journal of Gastroenterology : WJG·Wouter Willaert, Wim Ceelen
Mar 12, 2020·Annals of Surgical Treatment and Research·Han Deok KwakHyeong Rok Kim
Dec 30, 2020·The International Journal of Medical Robotics + Computer Assisted Surgery : MRCAS·Wanda PetzGiuseppe Spinoglio
Mar 16, 2021·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·Dimitrios E MagouliotisGeorge A Tzovaras
Sep 22, 2020·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Zachariah Gene Wing OwChoon Seng Chong

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