Short-term reverberant memory model of hippocampal field CA3

Hippocampus
S P WiebeJ Ambros-Ingerson

Abstract

Synaptic plasticity mechanisms for associative learning require near-simultaneous pairs of inputs to target cells. Sensory cues encountered behaviorally, however, are typically staggered in time, implying the need for active short-term memory traces of antecedent cues. The dense recurrent connectivity within regions of hippocampal field CA3 is suggestive of the kind of re-entrant network that could subserve this kind of "holding" memory. Consequently, we have investigated whether an abstract model of this region incorporating its major anatomical and physiological features could function as a reverberatory memory network. The continuous-time model describes the behavior of highly connected groups of CA3 pyramidal cells, or "patches," in response to brief, rhythmic, sensory stimulation. Time constants for excitatory and inhibitory postsynaptic potentials and axonal transmission delays for local and distal connections were estimated from empirical data. When the inhibitory units in these patches were connected to an oscillator intended to model the theta wave activity of the medial septum, the network entered reverberatory states and maintained second-long memory traces of the cortical input, after which it lost its coherent beha...Continue Reading

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Citations

May 13, 2003·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Susumu TonegawaMatthew A Wilson
May 9, 2013·The European Journal of Neuroscience·Arthur Jochems, Motoharu Yoshida
Mar 16, 2007·The European Journal of Neuroscience·Wendy Herrera-MoralesFederico Bermúdez-Rattoni
Dec 17, 2020·International Journal of Molecular Sciences·Daniele LanaMaria Grazia Giovannini
Apr 21, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Paul E Gilbert, Andrea M Brushfield

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