Short-term side effects of 0.2% alcohol-free chlorhexidine mouthrinse used as an adjunct to non-surgical periodontal treatment: a double-blind clinical study

Journal of Periodontology
Cem A GürganEmel Soykan

Abstract

The aims of this clinical study were to evaluate the short-term subjective (by means of questionnaire) and objective (by means of clinical examination) side effects of 0.2% chlorhexidine (CHX) mouthrinse without alcohol used as an adjunct to non-surgical periodontal treatment and to elucidate the relationship between the subjective and objective evaluations. This was a randomized, double-blind, placebo-controlled clinical trial with two groups: 1) the test group, rinsing with the test product (0.2% CHX without alcohol) twice per day for 1 week, and 2) the control (placebo) group, rinsing with a placebo solution twice per day for 1 week. Following the start of rinsing, patients were subjectively and objectively evaluated for the presence and severity of side effects (pain, burning sensation, pruritus, dryness of mouth, taste disturbance, mucosal irritations, and discoloration of tooth and tongue surfaces) at days 1, 3, and 7 of the rinsing period. The presence of subjective and objective side effects of the groups was compared via use of chi2 and Fisher exact tests. Analysis of the subjective and objective side effects within the evaluation periods was done by McNemar test. Spearman correlation analysis was used to assess the re...Continue Reading

References

Jun 1, 1976·Journal of Periodontal Research·H LöeT Karring
Apr 1, 1991·Oral Surgery, Oral Medicine, and Oral Pathology·B K MoghadamR E Gier
Jan 1, 1990·Oral Surgery, Oral Medicine, and Oral Pathology·J B Epstein
Oct 1, 1989·Journal of Clinical Periodontology·P BarkvollK Svendsen
Feb 1, 1988·International Journal of Oral and Maxillofacial Surgery·H U HepsøL A Skoglund
Jan 1, 1988·Journal of Clinical Periodontology·N P LangA A Antczak
May 1, 1985·Journal of Clinical Periodontology·H M EriksenJ E Ellingsen
Jan 1, 1974·Journal of Clinical Periodontology·P Gjermo
Jan 1, 1973·Journal of Periodontal Research. Supplement·L G HjeljordP Bonesvoll
Nov 1, 1967·Journal of Periodontology·H Löe
Feb 1, 1984·Acta Odontologica Scandinavica·H NordbøH M Eriksen
Jan 1, 1980·Acta Odontologica Scandinavica·H SolheimH Nordbø
May 1, 1995·Journal of Periodontal Research·S J BolanowskiS V Sutton
Oct 1, 1995·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·E Gagari, S Kabani
Oct 1, 1995·Archives of Oral Biology·J A HelmsM E Frank
Apr 1, 1996·The Journal of the American Dental Association·M Rosenberg
Jun 27, 1998·Periodontology 2000·C G Jones
Nov 4, 1998·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·P VigeantH G Robson
Nov 26, 1998·The Journal of Prosthetic Dentistry·K R EldridgeJ D Kettering
Feb 16, 2000·Journal of Clinical Periodontology·L J GründemannG A van der Weijden
Mar 10, 2001·Chemical Senses·P A Breslin, C D Tharp
Sep 21, 2001·Physiology & Behavior·M E FrankT P Hettinger
Apr 2, 2002·Journal of Periodontology·J L Leyes BorrajoTorreira M Gallas
Sep 26, 2002·Journal of Periodontology·Kürşad S ErenHamit S Bostanci
Apr 2, 2003·Journal of Periodontology·Jan A M KeijserFridus A Van der Weijden
Jun 12, 2004·Journal of Clinical Periodontology·M QuirynenD van Steenberghe
Jul 20, 2004·Journal of Clinical Periodontology·Danielle A C Van StrydonckG A van der Weijden
Aug 25, 2004·Journal of Periodontal Research·Daniel Araki RibeiroDaisy Maria Favero Salvadori
Feb 3, 2006·International Journal of Dental Hygiene·F BernardiL Montebugnoli

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Citations

Aug 26, 2009·Chemical Senses·Miao-Fen WangMarion E Frank
Feb 18, 2016·International Journal of Biomaterials·Farnaz HajifattahiMohammad Kamalinejad
Sep 10, 2015·Archives of Oral Biology·Azadeh Rahmani-BadiHamta Babaie-Naiej
Apr 5, 2016·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Stefania BalloniLorella Marinucci
Nov 6, 2015·Journal of International Society of Preventive & Community Dentistry·Ashwini MaiyaAmitha M Hegde
Jul 17, 2015·Journal of Conservative Dentistry : JCD·Fahimeh Sadat TabatabaeiFateme Javand
May 20, 2015·Journal of International Society of Preventive & Community Dentistry·Mohan JothikaBattu Someshwar
Jan 30, 2014·Brazilian Dental Journal·Karen Tereza AltieriCarlos Eduardo Vergani
Jan 1, 2008·Brazilian Oral Research·Celso Augusto Lemos, Germano Eduardo Miguel Villoria
Aug 21, 2014·Journal of Dental Research·C J BacklundM H Schoenfisch
Jun 2, 2018·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Sadiye GunpinarGizem Soyler
Mar 31, 2019·Molecular Oral Microbiology·Nao SuzukiTakashi Hanioka
Dec 23, 2017·Journal of Breath Research·Kavitha SeerangaiyanEdwin G Winkel
Feb 16, 2016·International Journal of Dental Hygiene·K Dhingra, K L Vandana
Oct 4, 2019·Therapeutic Advances in Drug Safety·Gianluca M TartagliaConchita Martín
Jul 13, 2020·Journal of Biomedical Materials Research. Part a·Evan S FeuraMark H Schoenfisch
Aug 22, 2008·Periodontology 2000·John M Moran
Nov 6, 2020·Journal of Pharmacy & Bioallied Sciences·Arthiie ThangaveluRajasekar Sundram
May 16, 2020·Current Pharmaceutical Design·Beáta KerémiGábor Varga
Feb 1, 2019·Applied Sciences·Sheng-Xue XieCandan Tamerler

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