Short-term sleep deprivation impairs spatial working memory and modulates expression levels of ionotropic glutamate receptor subunits in hippocampus

Behavioural Brain Research
Meilan XieJiali Wang

Abstract

Hippocampus-dependent learning memory is sensitive to sleep deprivation (SD). Although the ionotropic glutamate receptors play a vital role in synaptic plasticity and learning and memory, however, whether the expression of these receptor subunits is modulated by sleep loss remains unclear. In the present study, western blotting was performed by probing with specific antibodies against the ionotropic α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor subunits GluA1, GluA2, GluA3, and against the N-methyl-d-aspartate (NMDA) glutamate receptor subunits GluN1, GluN2A, GluN2B. In hippocampus, down regulation of surface GluA1 and GluN2A surface expression were observed in both SD groups. However, surface expression level of GluA2, GluA3, GluN1 and GluN2B was significantly up-regulated in 8h-SD rats when compared to the 4h-SD rats. In parallel with the complex changes in AMPA and NMDA receptor subunit expressions, we found the 8h-SD impaired rat spatial working memory in 30-s-delay T-maze task, whereas no impairment of spatial learning was observed in 4h-SD rats. These results indicate that sleep loss alters the relative expression levels of the AMPA and NMDA receptors, thus affects the synaptic strength and capacity...Continue Reading

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Citations

Mar 9, 2018·CNS Drugs·Panos ZanosTodd D Gould
Apr 9, 2017·Neuroscience Bulletin·Chao He, Zhian Hu
Jul 7, 2017·Sleep and Biological Rhythms·Yusuf PatrickJames Moss
Jul 2, 2020·Journal of Circadian Rhythms·Mojtaba Elhami AtharAhmad Ashouri
Mar 23, 2017·Molecular Psychiatry·M J Ramaker, S C Dulawa
Mar 28, 2021·Biochemical Pharmacology·Marcos G Frank

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