Short-Term Sleep Disturbance-Induced Stress Does not Affect Basal Pain Perception, but Does Delay Postsurgical Pain Recovery

The Journal of Pain : Official Journal of the American Pain Society
Po-Kai WangYuan-Xiang Tao

Abstract

Chronic sleep disturbance-induced stress is known to increase basal pain sensitivity. However, most surgical patients frequently report short-term sleep disturbance/deprivation during the pre- and postoperation periods and have normal pain perception presurgery. Whether this short-term sleep disturbance affects postsurgical pain is elusive. Here, we report that pre- or postexposure to rapid eye movement sleep disturbance (REMSD) for 6 hours daily for 3 consecutive days did not alter basal responses to mechanical, heat, and cold stimuli, but did delay recovery in incision-induced reductions in paw withdrawal threshold to mechanical stimulation and paw withdrawal latencies to heat and cold stimuli on the ipsilateral side of male or female rats. This short-term REMSD led to stress shown by an increase in swim immobility time, a decrease in sucrose consumption, and an increase in the level of corticosterone in serum. Blocking this stress via intrathecal RU38486 or bilateral adrenalectomy abolished REMSD-caused delay in recovery of incision-induced reductions in behavioral responses to mechanical, heat, and cold stimuli. Moreover, this short-term REMSD produced significant reductions in the levels of mu opioid receptor and kappa opi...Continue Reading

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Citations

May 10, 2017·Nature Medicine·Chloe AlexandreClifford J Woolf
May 10, 2020·Interface Focus·Mathieu NolletNicholas P Franks
Aug 3, 2020·The Journal of Pain : Official Journal of the American Pain Society·Xue TianYuan-Xiang Tao
Jun 25, 2021·Frontiers in Medicine·Dandan LinAnshi Wu

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