Short-term stability of subtypes in the irritable bowel syndrome: prospective evaluation using the Rome III classification

Alimentary Pharmacology & Therapeutics
A L EngsbroP Bytzer

Abstract

In irritable bowel syndrome (IBS) subtyping is used in research and clinical practice. Knowledge of subtype stability is needed for proper design of trials and treatment strategies. To evaluate the stability of Rome III IBS subtypes over time and to determine the optimal time period for prospective, diary-based subtyping. Rome III IBS patients aged 18-70 years enrolled in two identical, randomised, placebo-controlled trials of probiotics, were included. No difference was found on stool pattern, thus patients were analysed as one group. Patients scored defaecations according to Bristol Stool Form Scale for 10 weeks. IBS subtypes were determined for all 1- and 2-week periods. Subtype distribution and stool pattern over time were determined. The proportions of patients having the same subtype all weeks (stable patients) or having a predominant subtype (same subtype ≥60% of time) were determined. A total of 126 patients, mean age 46 ± 15 years, 72% women were included. Subtype distribution was similar over time with IBS with constipation, IBS with diarrhoea and IBS unsubtyped constituting one-third of the population each. Even though only 18-35% had the same subtype all weeks, the majority of patients had the same subtype for ≥60% ...Continue Reading

References

Dec 1, 1991·Statistics in Medicine·D G Altman
Feb 17, 1990·BMJ : British Medical Journal·L J O'DonnellK W Heaton
Sep 23, 1997·Scandinavian Journal of Gastroenterology·S J Lewis, K W Heaton
Nov 28, 2002·Gastroenterology·UNKNOWN American Gastroenterology Association
Dec 23, 2003·The American Journal of Gastroenterology·Fermin MearinIsabel Pérez
Mar 15, 2005·Gastroenterology·Douglas A DrossmanShrikant I Bangdiwala
Mar 24, 2005·The American Journal of Gastroenterology·Kirsten TillischLin Chang
Apr 22, 2005·The American Journal of Gastroenterology·Magda GuileraFermín Mearin
Jan 6, 2006·Alimentary Pharmacology & Therapeutics·R E WilliamsS F Cook
May 9, 2006·Gastroenterology·George F LongstrethRobin C Spiller
Feb 28, 2007·European Journal of Gastroenterology & Hepatology
May 10, 2007·Gut·R SpillerUNKNOWN Clinical Services Committee of The British Society of Gastroenterology
Apr 19, 2008·The New England Journal of Medicine·Emeran A Mayer
Oct 3, 2008·International Journal of Nursing Studies·Kay I PennyIan D Penman
Jul 21, 2009·Current Gastroenterology Reports·Brennan M R Spiegel
Jul 23, 2009·Journal of Clinical Gastroenterology·Spencer D DornDouglas A Drossman
Dec 23, 2009·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A DeiterenA R Zinsmeister
Apr 8, 2010·The American Journal of Gastroenterology·Robin C Spiller, W Grant Thompson
Apr 9, 2010·Alimentary Pharmacology & Therapeutics·M ColettaG Basilisco
Apr 24, 2010·Alimentary Pharmacology & Therapeutics·A C Ford, P Moayyedi
Feb 22, 2011·Gastroenterology Clinics of North America·Rok Seon Choung, G Richard Locke

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Citations

Feb 4, 2014·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Mariella M SelfRobert J Shulman
Mar 20, 2013·Scandinavian Journal of Gastroenterology·Laura Rindom KrogsgaardPeter Bytzer
Mar 29, 2014·Current Medical Research and Opinion·Brooks D Cash
Mar 13, 2012·Alimentary Pharmacology & Therapeutics·R K Wong, D A Drossman
May 18, 2012·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·S LudidiA A M Masclee
Mar 17, 2012·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A L EngsbroP Bytzer
Mar 15, 2015·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Imran AzizAlexander C Ford
Feb 4, 2014·The Journal of Pediatrics·Eleonora GiannettiAnnamaria Staiano
May 5, 2016·Gastroenterology·Fermín MearinRobin Spiller
Mar 18, 2017·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J Tack, D A Drossman
Sep 20, 2012·Revista latino-americana de enfermagem·Anna Paula Martinez, Gisele Regina de Azevedo
May 17, 2018·Expert Review of Gastroenterology & Hepatology·Russell DolanShanti Eswaran
Sep 28, 2018·Panminerva Medica·Alessandro AdrianiRinaldo Pellicano
May 29, 2015·Journal of Pediatric Gastroenterology and Nutrition·James W VarniUNKNOWN Pediatric Quality of Life Inventory Gastrointestinal Symptoms Module Testing Study Consortium
May 29, 2015·Journal of Pediatric Gastroenterology and Nutrition·James W VarniUNKNOWN Pediatric Quality of Life Inventory Gastrointestinal Symptoms Module Testing Study Consortium
Apr 5, 2017·Current Gastroenterology Reports·Magnus SimrenWilliam E Whitehead
Jun 23, 2018·Nature Reviews. Gastroenterology & Hepatology·Magnus Simrén, Jan Tack
Sep 10, 2019·Frontiers in Microbiology·Yu GuHailong Cao
Aug 14, 2020·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Carol Ireton-Jones, Michael F Weisberg
Nov 20, 2016·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·L R KrogsgaardP Bytzer
Jan 14, 2017·World Journal of Gastroenterology : WJG·Anna LyraLea Veijola
Oct 1, 2016·World Journal of Gastroenterology : WJG·Duo-Chen JinBang-Mao Wang
Oct 4, 2020·The American Journal of Gastroenterology·Brigida BarberioAlexander C Ford
May 29, 2021·Microbial Pathogenesis·Jun-Jie HouBang-Mao Wang
Sep 18, 2021·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Vivek C GoodooryAlexander C Ford

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