PMID: 2120516Aug 14, 1990Paper

Short-term stimulatory effect of Sertoli cell conditioned medium on Leydig cell steroidogenesis is not mediated by inhibin

Journal of Steroid Biochemistry
A J GrootenhuisF H de Jong

Abstract

Addition of concentrated rat Sertoli cell conditioned medium (rSCCM) to isolated Leydig cells from immature rats stimulated steroid production more than 13-fold within 4 h. LH-stimulated steroidogenesis was not enhanced by addition of rSCCM. The biological activity of the concentrated rSCCM was higher after incubation of Sertoli cells with FSH, whereas FSH alone did not stimulate steroid production. This effect of rSCCM was not due to inhibin, since highly purified 32 kDa rat inhibin, in doses equivalent to those present in rSCCM, had no effect on steroidogenesis during the 4 h incubation period. Furthermore, inhibin could be separated from the Leydig cell stimulating factor by anion-exchange chromatography. These results indicate a short-term paracrine control of Leydig cell steroidogenesis by Sertoli cell derived factors, which differ from inhibin.

References

Feb 1, 1979·Molecular and Cellular Endocrinology·K A RichD M de Kretser
Sep 1, 1976·Endocrinology·A Steinberger, E Steinberger
Mar 26, 1990·Molecular and Cellular Endocrinology·A J GrootenhuisF H de Jong
Jun 1, 1989·Molecular and Cellular Endocrinology·R MelsertF F Rommerts
Apr 1, 1985·Molecular and Cellular Endocrinology·G Verhoeven, J Cailleau
Feb 1, 1987·Molecular and Cellular Endocrinology·T A BicsakA J Hsueh
Jun 1, 1986·The Journal of Endocrinology·A M Ultee-van GesselH J van der Molen
Aug 29, 1986·Biochemical and Biophysical Research Communications·M BenahmedM A Chauvin
Oct 1, 1988·Molecular and Cellular Endocrinology·R MelsertF F Rommerts
Jul 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·A J HsuehW Vale
Sep 1, 1987·The Journal of Endocrinology·V PapadopoulosS Carreau
Oct 30, 1985·Biochemical and Biophysical Research Communications·M BenahmedA M Morera
Feb 1, 1984·Biology of Reproduction·R M Sharpe
Nov 21, 1998·Neuroendocrinology·E CarroC Diéguez

❮ Previous
Next ❯

Citations

Apr 1, 1992·Baillière's Clinical Endocrinology and Metabolism·D M RobertsonD M de Kretser
Aug 1, 1993·The Journal of Urology·D J Lamb

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.