PMID: 653740Feb 1, 1978Paper

Short-term toxicity of allyl alcohol in rats

Toxicology
F M CarpaniniA G Lloyd

Abstract

Groups of 15 male and 15 female rats were give 0 (control), 50, 100, 200 or 800 ppm allyl alcohol in the drinking water for 15 weeks. There were no effects attributable to allyl alcohol in the results of the haematological examinations or analyses of serum. There was a dose-related reduction in the fluid intake at all treatment levels in both sexes, while growth and food consumption were reduced in both sexes given 800 ppm and in males give 200 ppm. Males given 100 ppm or above and females given 200 or 800 ppm produced less urine than the controls in a period without water or following a water load. The only changes in organ weight that could be attributed to treatment were increased values for the relative weights of liver, spleen and kidney. All 3 organs were affected in both sexes given 800 ppm and the kidneys were also affected in both sexes given 200 ppm and in females given 100 ppm. No effects attributable to allyl alcohol treatment were seen at autopsy or in the histopathological examination. The no-untoward-effect level established in this study was 50 ppm of the drinking water, a level equivalent to an intake in rats of between 4.8 and 6.2 mg allyl alcohol/kg/day.

References

Feb 1, 1974·Food and Cosmetics Toxicology·S D GangolliA G Lloyd

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Citations

Oct 1, 1977·Food and Cosmetics Toxicology·T J GrayS D Gangolli
Apr 11, 2001·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·I C Munro, E Kennepohl
Sep 1, 1996·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·I C MunroJ G Sprenger
Apr 1, 1987·Food Additives and Contaminants·J C PhillipsS D Gangolli
Dec 1, 1978·Food and Cosmetics Toxicology·R J HendyP Grasso
Jul 25, 2014·International Journal of Occupational Medicine and Environmental Health·Marek Jakubowski, Sławomir Czerczak
Mar 31, 2015·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A M ApiD K Wilcox
Mar 31, 2015·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A M ApiD K Wilcox
Aug 1, 1978·Food and Cosmetics Toxicology·J J DrakeP Grasso
Aug 1, 1981·Journal of the Science of Food and Agriculture·P PrincipeP Comba
May 8, 2010·International Journal of Toxicology·Shakil A SaghirWilliam M Snellings
Jul 15, 2005·World Journal of Gastroenterology : WJG·Ming-Ling ChangJeng-Chang Chen

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