Short-term training attenuates muscle TCA cycle expansion during exercise in women

Journal of Applied Physiology
Kristen D DawsonMartin J Gibala

Abstract

Muscle glycogenolytic flux and lactate accumulation during exercise are lower after 3-7 days of "short-term" aerobic training (STT) in men (e.g., Green HJ, Helyar R, Ball-Burnett M, Kowalchuk N, Symon S, and Farrance B. J Appl Physiol 72: 484-491, 1992). We hypothesized that 5 days of STT would attenuate pyruvate production and the increase in muscle tricarboxylic acid cycle intermediates (TCAI) during exercise, because of reduced flux through the reaction catalyzed by alanine aminotransferase (AAT; pyruvate + glutamate <--> 2-oxoglutarate + alanine). Eight women [22 +/- 1 yr, peak oxygen uptake (Vo2 peak) = 40.3 +/- 4.6 ml. kg-1. min-1] performed seven 45-min bouts of cycle exercise at 70% Vo2 peak over 9 days (1 bout/day; rest only on days 2 and 8). During the first and last bouts, biopsies (vastus lateralis) were obtained at rest and after 5 and 45 min of exercise. Muscle glycogen concentration was approximately 50% higher at rest after STT (493 +/- 38 vs. 330 +/- 20 mmol/kg dry wt; P <or= 0.05), and net glycogenolysis and lactate accumulation were reduced after 5 min of exercise by 59 and 49%, respectively (P <or= 0.05). The net increase in four measured TCAI was approximately 40% lower (P <or= 0.05) during exercise after t...Continue Reading

References

Feb 1, 1992·Journal of Applied Physiology·H J GreenB Farrance
May 1, 1991·Journal of Applied Physiology·A BonenT E Graham
Mar 1, 1991·The American Journal of Physiology·M K SpencerI Raz
May 1, 1990·International Journal of Sports Medicine·A J WagenmakersR H Edwards
Nov 1, 1990·The American Journal of Physiology·K SahlinS Broberg
Aug 1, 1989·International Journal of Sports Medicine·B J NicklasR L Sharp
Apr 1, 1985·Clinical Physiology·J BergströmE Hultman
Oct 1, 1986·The American Journal of Physiology·J HenrikssonO H Lowry
Mar 1, 1982·The American Journal of Physiology·C S HintzO H Lowry
Apr 1, 1995·Canadian Journal of Physiology and Pharmacology·H J GreenG Jamieson
Sep 1, 1995·Canadian Journal of Applied Physiology = Revue Canadienne De Physiologie Appliquée·H J GreenG Jamieson
Feb 1, 1996·The American Journal of Physiology·A ChesleyL L Spriet
Aug 1, 1997·The Journal of Physiology·M J GibalaB Saltin
Aug 5, 1998·The American Journal of Physiology·C T PutmanG J Heigenhauser
Mar 10, 1999·The American Journal of Physiology·D Constantin-TeodosiuP L Greenhaff
Jul 17, 1999·The American Journal of Physiology·H GreenD Ranney
Dec 22, 1999·Acta Physiologica Scandinavica·A C Hackney
Mar 20, 2001·American Journal of Physiology. Endocrinology and Metabolism·M BruceJ L Bowtell
Sep 12, 2001·American Journal of Physiology. Endocrinology and Metabolism·S E CampbellM A Febbraio
Mar 8, 2002·American Journal of Physiology. Endocrinology and Metabolism·Tracy J HortonKathleen Tench
Oct 23, 2002·Journal of Applied Physiology·Sang-Hoon SuhGeorge A Brooks

❮ Previous
Next ❯

Citations

Oct 22, 2008·Proceedings of the National Academy of Sciences of the United States of America·Douglas E BefroyGerald I Shulman
Nov 23, 2006·European Journal of Applied Physiology·Simon Marwood, Joanna L Bowtell
Mar 15, 2012·Developmental Psychobiology·Bryan Kolb, G Campbell Teskey
Apr 11, 2006·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Mark A Tarnopolsky
Dec 9, 2004·Current Opinion in Clinical Nutrition and Metabolic Care·Erica P A RuttenNicolaas E P Deutz
May 4, 2004·Journal of Applied Physiology·Krista R HowarthMartin J Gibala

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.