Short-term transcriptome and microRNAs responses to exposure to different air pollutants in two population studies.

Environmental Pollution
Almudena Espín-PérezTheo M C M de Kok

Abstract

Diesel vehicle emissions are the major source of genotoxic compounds in ambient air from urban areas. These pollutants are linked to risks of cardiovascular diseases, lung cancer, respiratory infections and adverse neurological effects. Biological events associated with exposure to some air pollutants are widely unknown but applying omics techniques may help to identify the molecular processes that link exposure to disease risk. Most data on health risks are related to long-term exposure, so the aim of this study is to investigate the impact of short-term exposure (two hours) to air pollutants on the blood transcriptome and microRNA expression levels. We analyzed transcriptomics and microRNA expression using microarray technology on blood samples from volunteers participating in studies in London, the Oxford Street cohort, and, in Barcelona, the TAPAS cohort. Personal exposure levels measurements of particulate matter (PM10, PM2.5), ultrafine particles (UFPC), nitrogen oxides (NO2, NO and NOx), black carbon (BC) and carbon oxides (CO and CO2) were registered for each volunteer. Associations between air pollutant levels and gene/microRNA expression were evaluated using multivariate normal models (MVN). MVN-models identified comp...Continue Reading

Citations

Mar 19, 2019·Journal of Cellular Physiology·Zheng LiJianxiong Shen
Aug 3, 2019·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Michail Kotsyfakis, Evridiki Patelarou
Jan 18, 2020·Environmental Health Perspectives·Felicia Fei-Lei Chung, Zdenko Herceg
Jun 20, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Amina KunovacJohn M Hollander
Jul 10, 2019·Experimental and Therapeutic Medicine·Jin XieWenxing Fan
Jun 23, 2020·Journal of Alzheimer's Disease : JAD·Rui-Ming LiuJiu-Chiuan Chen
Sep 24, 2020·International Journal of Environmental Health Research·Kaili ZouXiaoli Fu
Aug 1, 2019·Journal of Molecular Neuroscience : MN·Mohammad Mahdi EftekharianSoudeh Ghafouri-Fard
Jul 4, 2020·Environment International·Paolo VineisSonia Dagnino
Jan 23, 2021·Journal of Personalized Medicine·Michal SimaPavel Rossner
Apr 7, 2020·Environment International·Lina MadaniyaziYuming Guo

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