PMID: 9556136Apr 29, 1998Paper

Short-term treatment of recombinant murine interleukin-4 rapidly inhibits bone formation in normal and ovariectomized mice

Bone
Y OkadaS Eto

Abstract

Estrogen deficiency contributes to an increase in bone resorption and bone formation characterized by a high rate of bone turnover. Interleukin-4 (IL-4) is a rapid and potent inhibitor of bone resorption. We examined the short term in vivo effects of recombinant murine IL-4 (rmIL-4) on bone remodeling in normal and ovariectomized mice. Eight-week-old mice were randomized into the following five groups: (1) sham-operated mice (sham); (2) sham-operated mice infused with rmIL-4; (3) ovariectomized mice (ovx); (4) ovx infused with rmIL-4; and (5) ovx replaced by 10 or 20 microg of 17beta-estradiol (E2) for 14 or 28 days after ovariectomy, respectively. rmIL-4 at a dose of 5 microg/day was infused into ovx and sham for 3 days prior to sacrifice. Analyses were performed 14 and 28 days after operation. An increase in serum alkaline phosphatase and urinary deoxypyridinoline levels induced by ovariectomy was inhibited by the 3-day infusion of rmIL-4. In ovx, serum and urinary IL-6 levels were also increased significantly 14 days after ovariectomy, which were restored by E2 but not by rmIL-4. Histomorphometrical analysis of trabecular bone revealed that the 3-day infusion of rmIL-4 inhibited the high rate of bone turnover induced by ovar...Continue Reading

References

Dec 30, 1992·Biochemical and Biophysical Research Communications·K UenoY Koshihara
Nov 15, 1990·Biochemical and Biophysical Research Communications·K WatanabeS Eto
Sep 1, 1990·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S H RalstonM Gowen
Jan 1, 1989·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·G N Andersson, S C Marks
Apr 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·R PacificiW A Peck
Nov 1, 1988·Endocrinology·N TakahashiT Suda
Mar 31, 1988·The New England Journal of Medicine·L G Raisz
Sep 22, 1988·The New England Journal of Medicine
Jun 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S H Ralston
Mar 27, 1993·Lancet·R Lindsay
Oct 1, 1993·Journal of Cellular Biochemistry·D L LaceyJ Ohara
Dec 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·D B LewisR M Perlmutter
Feb 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M I LusterM Thompson
Apr 1, 1993·Bone and Mineral·J A RianchoJ Gonzalez-Macias

❮ Previous
Next ❯

Citations

Dec 14, 2011·Calcified Tissue International·Floor M LambersRalph Müller
Jun 10, 2006·Current Opinion in Rheumatology·Sun-Kyeong Lee, Joseph Lorenzo
Mar 6, 2013·Biochemia Medica·Janja ZupanJanja Marc
Jun 8, 2001·The Journal of Clinical Investigation·Y Abu-Amer
May 3, 2008·Endocrine Reviews·Joseph LorenzoYongwon Choi
Dec 10, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Marie K LindbergClaes Ohlsson
Sep 26, 2006·Pharmacoepidemiology and Drug Safety·Frank de VriesTjeerd-Pieter van Staa
Aug 7, 2008·BMB Reports·Seoung-Hoon LeeJoseph Lorenzo
Aug 12, 2004·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Carl-Johan SilfverswärdOsten Ljunggren
Feb 1, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ming HuAnastasios Karadimitris
Jul 3, 2021·Immunity, Inflammation and Disease·Munehiro NaruoRimpei Morita

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved