Short-term treatment with rapamycin and dietary restriction have overlapping and distinctive effects in young mice.

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Wilson C FokViviana I Pérez

Abstract

Because rapamycin, an inhibitor of the nutrient sensor mammalian target of rapamycin, and dietary restriction both increase life span of mice, it has been hypothesized that they act through similar mechanisms. To test this hypothesis, we compared various biological parameters in dietary restriction mice (40% food restriction) and mice fed rapamycin (14 ppm). Both treatments led to a significant reduction in mammalian target of rapamycin signaling and a corresponding increase in autophagy. However, we observed striking differences in fat mass, insulin sensitivity, and expression of cell cycle and sirtuin genes in mice fed rapamycin compared with dietary restriction. Thus, although both treatments lead to significant downregulation of mammalian target of rapamycin signaling, these two manipulations have quite different effects on other physiological functions suggesting that they might increase life span through a common pathway as well as pathways that are altered differently by dietary restriction and rapamycin.

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Citations

Aug 21, 2012·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Anna CsiszarZoltan Ungvari
Aug 16, 2013·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Jie SongChao-Yu Miao
Nov 12, 2014·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Yuxiang MaXiangmei Chen
Apr 24, 2014·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Zhen YuViviana I Pérez
May 24, 2016·International Journal of Molecular Sciences·Paula K Bautista-NiñoAnton J M Roks
Oct 22, 2015·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Yan Y LamEric Ravussin
Jul 6, 2019·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Peter C ReifsnyderDavid E Harrison
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Jan 25, 2019·Journal of Applied Physiology·Craig A Goodman
Jul 30, 2019·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Theresa MauRaymond Yung
Mar 12, 2019·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Archana UnnikrishnanArlan Richardson
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Jun 2, 2021·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Chen-Yu LiaoBrian K Kennedy
Nov 19, 2021·Science·Mitchell B LeeMatt Kaeberlein

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Methods Mentioned

BETA
Assay
electrophoresis
PCR

Software Mentioned

BLAST
Primer
ImageQuant

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