Short-term variability of blood pressure: effects of lower-body negative pressure and long-duration bed rest

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Federico AlettiR Hughson

Abstract

Mild lower-body negative pressure (LBNP) has been utilized to selectively unload cardiopulmonary baroreceptors, but there is evidence that arterial baroreceptors can be transiently unloaded after the onset of mild LBNP. In this paper, a black box mathematical model for the prediction of diastolic blood pressure (DBP) variability from multiple inputs (systolic blood pressure, R-R interval duration, and central venous pressure) was applied to interpret the dynamics of blood pressure maintenance under the challenge of LBNP and in long-duration, head-down bed rest (HDBR). Hemodynamic recordings from seven participants in the WISE (Women's International Space Simulation for Exploration) Study collected during an experiment of incremental LBNP (-10 mmHg, -20 mmHg, -30 mmHg) were analyzed before and on day 50 of a 60-day-long HDBR campaign. Autoregressive spectral analysis focused on low-frequency (LF, ~0.1 Hz) oscillations of DBP, which are related to fluctuations in vascular resistance due to sympathetic and baroreflex regulation of vasomotor tone. The arterial baroreflex-related component explained 49 ± 13% of LF variability of DBP in spontaneous conditions, and 89 ± 9% (P < 0.05) on day 50 of HDBR, while the cardiopulmonary barore...Continue Reading

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Citations

Jun 4, 2013·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Alessandra AdamiGuido Ferretti
Jan 17, 2015·IEEE Transactions on Bio-medical Engineering·Amirehsan Sarabadani TafreshiRobert Riener
Aug 4, 2016·Journal of Clinical Monitoring and Computing·Kavita YadavK K Deepak
Jan 4, 2021·European Journal of Applied Physiology·Vegard Bruun Bratholm WyllerJ Philip Saul

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