PMID: 7545428May 1, 1995Paper

Short-term weekly chemotherapy followed by high-dose therapy with autologous bone marrow transplantation for lymphoblastic and Burkitt's lymphomas in adult patients

Annals of Oncology : Official Journal of the European Society for Medical Oncology
L M JostR A Stahel

Abstract

Type and duration of treatment for highly aggressive non-Hodgkin's lymphoma has been a matter of debate over the past decade. To determine the therapeutic efficacy of an abbreviated treatment regimen, 26 patients with newly-diagnosed highly aggressive lymphomas, 17 of them belonging to the International Working Formulation (IWF) group I and 9 with Burkitt's lymphoma (IWF J), were entered in a study using short-term weekly chemotherapy followed by high-dose therapy and autologous bone marrow transplantation. Besides histology, requirements for entry into to the study were age between 16 and 60 years, stage 1 bulky disease and elevated LDH or stage II to IV disease with or without bulk or elevated LDH, and an absence of HIV infection or CNS involvement at diagnosis. The treatment plan was 12 weeks of MACOP-B or VACOP-B chemotherapy followed by high dose therapy and autologous bone marrow transplantation in first complete remission. Twenty patients (76%), 16 (62%) of those on MACOP-B or VACOP-B, 1 who had received 2 cycles of ProMACE-CytaBOM prior to MACOP-B and 3 after a first salvage regimen, achieved complete remissions. Seventeen patients (65%) were transplanted in first remission, and 15 (58%) after induction treatment with o...Continue Reading

Citations

Mar 1, 2006·Expert Review of Anticancer Therapy·John Gerecitano, David J Straus
Feb 6, 2020·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Chun LiHua Wang
Sep 20, 2011·British Journal of Haematology·David C Linch
Aug 4, 2012·Bone Marrow Transplantation·S O AhmedM Aljurf
Dec 1, 2006·Current Hematologic Malignancy Reports·John W Sweetenham
Dec 1, 2006·Current Hematologic Malignancy Reports·Ian T Magrath
Aug 18, 2004·Current Opinion in Oncology·Yvette L Kasamon, Lode J Swinnen
Sep 26, 2012·The Cancer Journal·Craig A Portell, John W Sweetenham
Mar 20, 2001·Hematology/oncology Clinics of North America·D A Thomas, H M Kantarjian

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