Short-term weight gain and breast cancer risk by hormone receptor classification among pre- and postmenopausal women

Breast Cancer Research and Treatment
B RosnerGraham Colditz

Abstract

Obesity is well established as a cause of postmenopausal breast cancer incidence and mortality. In contrast, adiposity in early life reduces breast cancer incidence. However, whether short-term weight change influences breast cancer risk is not well known. We followed a cohort of 77,232 women from 1980 to 2006 (1,445,578 person-years), with routinely updated risk factor information, documenting 4196 incident cases of invasive breast cancer. ER and PR status were obtained from pathology reports and medical records yielding a total of 2033 ER+/PR+ tumors, 595 ER-/PR- tumors, 512 ER+/PR- tumors. The log incidence breast cancer model was used to assess the association of short-term weight gain (over past 4 years) while controlling for average BMI before and after menopause. Short-term weight change was significantly associated with breast cancer risk (RR 1.20; 95 % CI 1.09-1.33) for a 4-year weight gain of ≥15 lbs versus no change (≤5 lbs) (P_trend < 0.001). The association was stronger for premenopausal women (RR 1.38; 95 % CI 1.13-1.69) (P_trend = 0.004) than for postmenopausal women (RR 1.10; 95 % CI 0.97-1.25) (P_trend = 0.063). Short-term weight gain during premenopause had a stronger association for ER+/PR- (RR per 25 lb weig...Continue Reading

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Citations

Jan 29, 2016·Science Translational Medicine·Kelle H Moley, Graham A Colditz
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Mar 24, 2021·International Journal of Epidemiology·Merete Ellingjord-DaleUNKNOWN Additional Authors
Apr 13, 2021·Frontiers in Oncology·Shuwen DongXiaosong Chen
Apr 23, 2021·Breast Cancer : Targets and Therapy·Alex A DalyEllen R Copson

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Methods Mentioned

BETA
bilateral oophorectomy

Software Mentioned

EPIC

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