PMID: 11925458Apr 2, 2002Paper

Short-term zinc deficiency inhibits chondrocyte proliferation and induces cell apoptosis in the epiphyseal growth plate of young chickens

The Journal of Nutrition
Xibin WangR M Leach

Abstract

The purpose of this study was to investigate the effect of zinc deficiency on chondrocyte proliferation, differentiation and apoptosis in the epiphyseal growth plate of juvenile chickens. Newly hatched broiler chickens were fed either a low zinc (10 mg/kg diet) or a zinc-adequate (68 mg/kg diet) soy protein-based purified diet. Cell proliferation in the growth plate was evaluated with bromodeoxyuridine (BrdU) labeling. Apoptosis was assessed using the terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) method. Chondrocyte differentiation was evaluated with immunostaining of osteonectin as a marker of maturation. As early as d 3 of feeding, zinc deficiency significantly inhibited chondrocyte proliferation, promoted cell differentiation and induced cell apoptosis in the growth plate. These effects were manifested primarily in areas remote from the blood supply. Immunostaining for local growth factors such as insulin-like growth factor-1 (IGF-1), parathyroid hormone-related protein (PTHrP) and fibroblast growth factor-2 (FGF-2) did not reveal any differences between growth plates of zinc-deficient and zinc-adequate chickens after 3 d of feeding. By d 7, severe growth plate lesions characterized by reduced...Continue Reading

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Citations

Mar 7, 2017·Biological Trace Element Research·Sana BoughammouraImed Messaoudi
Jun 19, 2019·Asian-Australasian Journal of Animal Sciences·Cecep HidayatElizabeth Wina
Feb 16, 2020·International Journal of Molecular Sciences·Sana BoughammouraImed Messaoudi
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Mar 21, 2019·Acta Cirúrgica Brasileira·Patrícia Madalena San Gregório GuedesJosé Batista Volpon
Jul 26, 2019·Animals : an Open Access Journal From MDPI·L LiZ Jiang
Jan 7, 2019·Biological Trace Element Research·Gretchen Myers Hill, Marcia Carlson Shannon
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Apr 9, 2010·Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics·M Horvat-GordonR M Leach

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis