Short-wavelength automated perimetry in patients with diabetes mellitus without macular edema

Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
Andreas RemkyOliver Arend

Abstract

The short-wavelength-sensitive (SWS) cone-mediated sensitivity is a sensitive indicator of functional changes of the macula in diabetic maculopathy. This study was performed to investigate whether functional losses of the macula are detectable in patients without a significant macular edema. In 45 patients with diabetes mellitus with clear optical media and no macular edema, conventional white-on-white perimetry (WWP) and short-wavelength automated perimetry (SWAP) were performed in the central 10-deg field. Fifty-eight healthy subjects ranging in age from 16 to 62 years served as controls. The two groups did not differ in age. Variance analysis (ANOVA) revealed significantly lower sensitivity in patients with diabetes than in controls. SWAP thresholds were significantly more greatly reduced by diabetes than those of WWP (ANOVA interaction: P=0.003). Post-hoc testing revealed a sensitivity reduction of 2.8 dB ( P=0.0003) in patients with diabetes for SWAP versus 0.46 for WWP ( P=0.15). Subgroup analysis revealed that mean thresholds of SWAP and WWP predominantly were reduced in patients with advanced disease. In patients with no retinopathy, sensitivity was not affected at all. SWS sensitivity may be affected in patients with d...Continue Reading

Citations

Feb 9, 2013·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·C Erb, K Göbel
May 13, 2014·Indian Journal of Ophthalmology·Othman Ali ZicoEslam Elsayed Abdel-Hamid Ahmed
Sep 25, 2015·Documenta Ophthalmologica. Advances in Ophthalmology·A KurtenbachH Langrová
Sep 5, 2006·Progress in Retinal and Eye Research·Marcus A BearseShirin Barez
May 2, 2015·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·Carl Erb
Aug 3, 2005·Japanese Journal of Ophthalmology·Tsutomu SakaiKenji Kitahara
Sep 29, 2005·Acta Ophthalmologica Scandinavica·Efty P Stavrou, Joanne M Wood

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