Shortcomings in pharmacokinetic analysis by conceiving the body to exhibit properties of a single compartment
No abstract listed.
Role of pharmacokinetics in drug dosage adjustment. I. Pharmacologic effect kinetics and apparent volume of distribution of digoxin
Pharmacokinetics of creatinine in man and its implications in the monitoring of renal function and in dosage regimen modifications in patients with renal insufficiency
Rapid estimation of volume of distribution after a short intravenous infusion and its application to dosing adjustments
Pharmacokinetic characterization of the postdistribution phase of prohormone atrial natriuretic peptides amino acids 1-98, 31-67, and atrial natriuretic factor during and after rapid right ventricular pacing in dogs
A linear systems approach to analyzing the pharmacokinetics of carbon tetrachloride in the rat following repeated exposures of 8 and 11.5 h/day
Pharmacokinetics of tolfenamic acid: disposition in bile, blood and urine after intravenous administration to man
Pharmacokinetics and hypotensive effect in healthy volunteers of pinacidil, a new potent vasodilator
Pharmacokinetics and absolute bioavailability of carteolol, a new beta-adrenergic receptor blocking agent
Butylbiguanide concentration in plasma, liver, and intestine after intravenous and oral administration to man
Pharmacokinetics of nortriptyline in man after single and multiple oral doses: the predictability of steady-state plasma concentrations from single-dose plasma-level data
Pharmacokinetics and quantitative characterization of cefotiam excretion after intravenous administration to patients after cholecystectomy
Pharmacokinetics of the anticonvulsant drug clonazepam evaluated from single oral and intravenous doses and by repeated oral administration
Apparent pharmacokinetics of PCB components in growing pigs and lambs when fed a ration containing Aroclor 1254
Pharmacokinetics of intravenous amikacin after rapid and slow infusion with special reference to hemodialysis
Pharmacokinetics and metabolism of a new beta-adrenergic blocking agent, the 1, ter-butyl-amino-3-(1,2,3,4-tetrahydro-1,4-ethano-8-hydroxy-5-naphthoxy)-2-propanol (K 5407)
Nonlinear least-squares regression analysis in pharmacokinetics: application of a programmable calculator in model parameter estimation
Application of clearance concepts to some literature data on drug metabolism in the isolated perfused liver preparation and in vivo
Pharmacokinetics of the enantiomers of hexobarbital studied in the same intact rat and in the same isolated perfused rat liver
Pharmacokinetics of the gonadotrophin inhibitor 19 beta-cis-ethyliden-17 alpha-ethynyl-17 beta-hydroxy-androstatrien-3-one (Ro 6-5403) in man
Pharmacokinetics of D,L-3-hydroxy-3-ethyl-3-phenylpropionamide (HEPP) in pregnant rats at different stages of gestation and maternal-fetal disposition during late pregnancy
Pharmacokinetics of progesterone after its administration to ovariectomized rhesus monkeys by injection, infusion, or nasal spraying
The pharmacokinetics of ephedrine after oral dosage in asthmatics receiving acute and chronic treatment
A study of factors influencing drug disposition in chronic liver disease, using the model drug (+)-propranolol
Pharmacokinetics of methyldopa. Plasma levels following single intravenous, oral and multiple oral dosage in normotensive and hypertensive subjects
Study of the in vitro pharmacological effects of gram-negative endotoxins in parallel with toxicity testing in normal adult guinea-pigs
Pharmacokinetic model for the successive demethylation and biliary secretion of methyl orange in the rat
The pharmacokinetics of valproic acid after oral and parenteral administration in healthy volunteers
A simple equation to estimate the fraction of drug remaining in the body after an intravenous injection
Plasma and cerebrospinal fluid concentrations of pentazocine in patients: assay by mass fragmentography
125I-labelled Rose Bengal in the quantitative estimation of fazadinium and other quaternary ammonium compounds in biological fluids
Pharmacokinetic interpretation of cephradine levels in serum after intravenous and extravascular administration in humans
Pharmacokinetics of amoxicillin: dose dependence after intravenous, oral, and intramuscular administration
Comparative pharmacokinetics of YM-13115, ceftriaxone, and ceftazidime in rats, dogs, and rhesus monkeys
Pharmacokinetic interpretation of blood levels and urinary excretion data for cefazolin and cephalothin after intravenous and intramuscular administration in humans
Pharmacokinetics of bupropion, a novel antidepressant agent, following oral administration to healthy subjects
Phagocytic activity of the rat reticuloendothelial system and the pharmacokinetics of an anticholinesterasic insecticide: carbaryl
Biotransformation of 10-(3-quinuclidinylmethyl)phenothiazine (LM 209), a new anti-allergy agent and the distribution and excretion of its metabolites
Absorption, distribution and excretion of (quinuclidinyl-3 methyl)-10-phenothiazine (LM 209), a new antihistamine
Oral absorption of griseofulvin in dogs: increased absorption via solid dispersion in polyethylene glycol 6000
Individual differences in the pharmacokinetics of monomethylated tricyclic antidepressants: role of genetic and environmental factors and clinical importance
Kinetic profile in blood and brain of the cholinesterase reactivating oxime HI-6 after intravenous administration to the rat
The enzyme inducing effect of rifampicin in the rhesus monkey and its lack of interaction with oral contraceptive steroids
Studies in rabbits on the disposition and trypanocidal activity of the anti-trypanosomal drug, diminazene aceturate (Berenil)
Mathematical considerations in the estimation of peak drug concentrations under uniform and nonuniform dosing conditions
The two-compartment open-system kinetic model: a review of its clinical implications and applications
Pharmacokinetics of flunitrazepam following single- and multiple-dose oral administration to healthy human subjects
Pharmacokinetic and biopharmaceutic profile of chlordiazepoxide HC1 in healthy subjects: single-dose studies by the intravenous, intramuscular, and oral routes
COMPT, a time-sharing program for nonlinear regression analysis of compartmental models of drug distribution
Compartment- and model-independent linear plateau principle of drugs during a constant-rate absorption or intravenous infusion
Pulmonary absorption and excretion of compounds in the gas phase: theoretical pharmacokinetic and toxicokinetic analysis
Comparative pharmacokinetics of coumarin anticoagulants. IV. Application of a three-compartmental model to the analysis of the dose-dependent kinetics of bishydroxycoumarin elimination
Pharmacokinetics of the novel anticonvulsant HEPP after single intravenous administration of three different doses in dogs
Two compartment analysis of plasma elimination of phenazone in normals and in patients with cirrhosis of the liver
Pharmacokinetics of absorption, distribution and elimination of fenfluramine and its main metabolite in man
On Dr Dick Climie and Dr Jack Thomas, and the genesis of chemical-clinical pharmacology in Australian anaesthesia research
Fifty-Eight Years and Counting: High-Impact Publishing in Computational Pharmaceutical Sciences and Mechanism-Based Modeling
Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.
Genetic Screens in iPSC-derived Brain Cells
Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.
Alzheimer's Disease: MS4A
Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.
Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.
Chronic Fatigue Syndrome
Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.
Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.
Pharmacology of Proteinopathies
This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.
This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.
Alignment-free Sequence Analysis Tools
Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.