Shortened hospital stay for childhood bone and joint infections: analysis of 265 prospectively collected culture-positive cases in 1983-2005

Scandinavian Journal of Infectious Diseases
Markus PääkkönenHeikki Peltola

Abstract

In recent decades the treatment of childhood acute bone and joint infections has shifted towards shorter antibiotic courses and rapid transition to oral therapy. We prospectively collected 265 culture-positive cases of non-neonatal bone and joint infections in Finnish children during 1983-2005. The duration of antimicrobial treatment and the extent of surgery were defined in the study protocol, but for ethical reasons, the liaison clinician determined the time of discharge using normalization of the serum C-reactive protein (CRP) level as a yardstick. We examined changes during the study in the distribution of causative organisms, severity of disease, and length of hospital stay. Staphylococcus aureus was overwhelmingly the most common causative agent throughout the study, whereas Haemophilus influenzae type b was eliminated soon after the introduction of vaccination. The mean time from initial symptoms to presentation remained the same at 4 days, and no significant change was observed in the severity of disease, CRP, or the rate of sequelae. The mean duration of intravenous antibiotic administration was only 4 days. The average hospital stay shortened significantly from 13 days to 9 days (p = 0.0001). The shortened hospital st...Continue Reading

References

Jan 1, 1997·Scandinavian Journal of Infectious Diseases·H BirgissonT Gudnason
Jun 10, 1998·The Journal of Bone and Joint Surgery. British Volume·H PeltolaL Unkila-Kallio
Jan 27, 2005·Journal of Paediatrics and Child Health·E D GoergensI R Barrett
Apr 19, 2005·Pediatric Surgery International·D MalciusA Kilda
May 24, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sheldon L KaplanEdward O Mason
Nov 2, 2005·The Journal of Bone and Joint Surgery. British Volume·C B D LavyA D Pitani
Sep 29, 2007·Annals of the Rheumatic Diseases·A J GeirssonA Víkingsson
Jan 30, 2008·Pediatrics·Øystein Rolandsen RiiseBerit Flatø
Sep 25, 2008·Journal of Pediatric Orthopedics·Omar A GafurShellye E Crawford
Mar 28, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Heikki PeltolaUNKNOWN Osteomyelitis-Septic Arthritis (OM-SA) Study Group
Jun 18, 2009·Clinical Orthopaedics and Related Research·Markus PääkkönenHeikki Peltola
Jul 2, 2009·Journal of Pediatric Orthopedics·Nikolas Alan JagodzinskiChristopher Edward Bache
Aug 28, 2009·Transactions of the Royal Society of Tropical Medicine and Hygiene·Christine M StanleyTitus Beyeza
Sep 1, 2009·The European Respiratory Journal·P K LorgellyT Stephenson
Oct 13, 2009·The Pediatric Infectious Disease Journal·Maria A Carrillo-MarquezSheldon L Kaplan
Feb 26, 2010·The Pediatric Infectious Disease Journal·Gal Dubnov-RazPablo Yagupsky
Mar 12, 2010·Journal of Pediatric Orthopedics. Part B·Markus PääkkönenPentti E Kallio
Aug 3, 2010·The Journal of Bone and Joint Surgery. British Volume·V L L BecklesW J Harrison
Sep 16, 2010·The Pediatric Infectious Disease Journal·Heikki PeltolaUNKNOWN Osteomyelitis-Septic Arthritis Study Group
Jun 7, 2011·International Journal of Antimicrobial Agents·M Pääkkönen, H Peltola
Sep 29, 2011·Archives of Disease in Childhood·M Pääkkönen, H Peltola
Jan 6, 2012·The Journal of Bone and Joint Surgery. American Volume·Mohan V BelthurJacob Weinberg

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Citations

Jun 1, 2013·Journal of the Pediatric Infectious Diseases Society·Markus PääkkönenHeikki Peltola
Feb 19, 2014·The Veterinary Clinics of North America. Food Animal Practice·André Desrochers, David Francoz
Mar 14, 2013·Pediatric Clinics of North America·Markus Pääkkönen, Heikki Peltola
Oct 1, 2015·Orthopaedics & Traumatology, Surgery & Research : OTSR·C AgoutC Bonnard
Aug 28, 2015·Infectious Disease Clinics of North America·John C Arnold, John S Bradley
May 26, 2016·Hospital Pediatrics·Jennifer Leontine MurphySarah K Parker
Jul 29, 2016·The Journal of the American Academy of Orthopaedic Surgeons·Alexandre ArkaderKenneth Noonan
Jul 15, 2017·The Pediatric Infectious Disease Journal·Jesús Saavedra-LozanoAnton LeMair
Sep 26, 2017·The Pediatric Infectious Disease Journal·Brenton JohnsDavid Dewar
May 23, 2015·The Journal of Bone and Joint Surgery. American Volume·Hilal Maradit KremersPaul M Huddleston
Mar 5, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Zaid AlhinaiIan C Michelow
Jan 18, 2019·Paediatrics & Child Health·Nicole Le Saux
Oct 3, 2020·JBJS Reviews·Alex L GornitzkyIshaan Swarup
Jul 1, 2014·Journal of Pediatric Orthopedics·Nicole I Montgomery, Scott Rosenfeld
Sep 25, 2019·International Journal of Environmental Research and Public Health·Elena ChiappiniUNKNOWN Italian Paediatric Collaborative Osteomyelitis Study Group
Apr 19, 2017·Journal of the Pediatric Infectious Diseases Society·Murray D SpruiellSarah K Parker

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