Shortened lifespan of nematode Caenorhabditis elegans after prolonged exposure to heavy metals and detergents

Ecotoxicology and Environmental Safety
Hiroaki HaradaToshihiko Eki

Abstract

The acute toxicities of heavy metals and detergents have been well examined with respect to several endpoints, such as mortality, for application to toxicity tests for environmental assessments. However, chronic influences of these agents on multicellular organisms still need to be determined. Here we studied long-term effects on the lifespan of a free-living nematode, Caenorhabditis elegans, resulting from prolonged exposure to heavy metals or detergents, as well as short-term inhibitory effects on reproduction and growth. These agents inhibited growth of hatched larvae and reproductive capacity in a concentration-dependent manner. They also effectively shortened the lifespan of the adult nematode over the same concentration range. Since toxic effects on both growth and lifespan were observed over similar concentration ranges, where acute toxicities in various endpoints are detected, the shortening of the lifespan can be used as a new endpoint for the assessment of various ecotoxic agents.

References

Oct 1, 1979·Environmental Research·J D Popham, J M Webster
May 1, 1974·Genetics·S Brenner
Jan 1, 1995·Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology·K GuvenD I de Pomerai
Nov 14, 1997·Archives of Environmental Contamination and Toxicology·D R HitchcockP L Williams
Jan 1, 2000·Journal of Toxicology and Environmental Health. Part a·R DhawanP L Williams
May 3, 2000·Archives of Environmental Contamination and Toxicology·C L Peredney, P L Williams
Mar 22, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·D BarsyteG J Lithgow
May 10, 2001·Environmental Toxicology and Chemistry·G L AndersonP L Williams
Mar 1, 2002·Mechanisms of Ageing and Development·Gordon J Lithgow, Glenda A Walker
Jun 11, 2003·Nature Genetics·Yong Hwan JinDmitry A Gordenin
Dec 12, 2003·Molecular Biology of the Cell·James F Morley, Richard I Morimoto
Jan 10, 2004·Environmental Toxicology and Chemistry·Windy A BoydPhillip L Williams
Jun 8, 2004·Environmental Toxicology and Chemistry·Gary L AndersonPhillip L Williams
Aug 11, 2004·Toxicology Letters·Koichi HasegawaJohji Miwa
Aug 27, 2004·Journal of Molecular Biology·S C SwainS R Stürzenbaum

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Citations

Apr 10, 2009·Environmental Monitoring and Assessment·Wei HaoWenju Liang
Jan 16, 2010·Journal of Toxicology and Environmental Health. Part a·Beke T SeseBrian J Reid
Oct 9, 2007·DNA Research : an International Journal for Rapid Publication of Reports on Genes and Genomes·Toshihiko EkiFumio Hanaoka
Aug 31, 2007·Toxicological Sciences : an Official Journal of the Society of Toxicology·Shunchang WangLijun Wu
Jul 4, 2009·Ecotoxicology and Environmental Safety·Xiaojuan XingDayong Wang
Sep 11, 2007·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Masaharu NakamuraToshihiko Eki
Aug 1, 2012·Environmental Toxicology and Chemistry·Pei-Chun L HsuMark R H Hurst
Jun 5, 2016·Archives of Biochemistry and Biophysics·Nicholas DietrichKerry Kornfeld
Jun 15, 2016·Marine Pollution Bulletin·Free Espinosa, Georgina A Rivera-Ingraham
Jun 28, 2016·Parasites & Vectors·Andreas J StroehleinRobin B Gasser
Aug 28, 2016·Toxicological Sciences : an Official Journal of the Society of Toxicology·Mamta BehlWindy A Boyd
Mar 15, 2018·Metallomics : Integrated Biometal Science·Lucie SauzéatVincent Balter
Jun 13, 2018·Annual Review of Analytical Chemistry·Farhan Kamili, Hang Lu
Nov 3, 2017·Environmental Toxicology and Chemistry·Fidelis MugovaDavid Spurgeon
Dec 15, 2010·Human & Experimental Toxicology·Daiana AvilaMichael Aschner
Nov 4, 2017·Environmental Science and Pollution Research International·Lesly Tejeda-BenítezJesus Olivero-Verbel
Oct 28, 2019·Ecotoxicology and Environmental Safety·Ana De la Parra-Guerra, Jesus Olivero-Verbel
May 26, 2021·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Kehinde D FasaeMichael Aschner
Jun 29, 2010·Ecotoxicology and Environmental Safety·Dayong WangLulu Shen

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