PMID: 8612189Jun 1, 1995Paper

Shortening of the hippocampal formation in first-episode schizophrenic patients

Psychiatry and Clinical Neurosciences
H FukuzakoK Takeuchi

Abstract

Shortening of hippocampal formation (HF) in chronic schizophrenic patients have been demonstrated in our previous study. The purpose of the present study is to test if shortening of the HF occurs in schizophrenic patients suffering their initial psychotic episode. We performed contiguous, 1 mm thick, magnetic resonance imaging scans in 20 first-episode schizophrenic patients, 21 chronic schizophrenic patients, and 25 healthy subjects. Both groups of schizophrenic patients demonstrated significant shortening of the HF compared with normal controls (first-episode schizophrenia, 5.3%; chronic schizophrenia, 8.0%). However, the HF length was not significantly different between the first-episode and chronic schizophrenic patients. No significant correlation was seen between the HF length and the duration of illness in chronic schizophrenic patients. These results suggest that the HF shortening observed in schizophrenic patients may be genetic and/or developmental in origin.

References

Sep 20, 1991·Science·L R Squire, S Zola-Morgan
Oct 1, 1991·Archives of General Psychiatry·B BogertsB Greve
Nov 1, 1989·Archives of General Psychiatry·D V Jeste, J B Lohr
Feb 1, 1988·The American Journal of Psychiatry·R C SheltonD R Weinberger
Jan 1, 1987·Neuropsychologia·S C SchachterN Geschwind
Jan 1, 1986·Journal of Neural Transmission·H Jakob, H Beckmann
Jan 1, 1986·European Archives of Psychiatry and Neurological Sciences·P Falkai, B Bogerts
Jan 1, 1985·Schizophrenia Bulletin·R M BilderA K Pandurangi
Aug 1, 1993·Schizophrenia Research·M Sarai, H Matsunaga
Feb 15, 1993·Biological Psychiatry·B BogertsS Masiar

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Citations

Mar 17, 2000·Brain Research. Brain Research Reviews·D CopolovC Pantelis
Nov 1, 2002·Schizophrenia Research·Lisa J PhillipsPatrick D McGorry
Sep 7, 2000·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·D GothelfA Weizman
Dec 15, 2007·Journal of the International Neuropsychological Society : JINS·Sophie RémillardHenri Cohen
Oct 16, 2001·Biological Psychiatry·D VelakoulisC Pantelis
Sep 29, 2005·Behavioral Neuroscience·Joseph R Manns, Howard Eichenbaum
Nov 29, 2007·PloS One·Masako Tsukamoto-YasuiYuji Ikegaya
Nov 13, 2009·PloS One·Christopher S RexGary Lynch
Sep 8, 2009·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·I González-BurgosC Beas-Zárate
Mar 15, 2000·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·M B JensenB Finsen

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