Shorter examination method for the diagnosis of misery perfusion with count-based oxygen extraction fraction elevation in 15O-Gas PET

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Masato KobayashiHidehiko Okazawa

Abstract

(15)O-Gas PET is useful for evaluating hemodynamic status in patients with ischemic cerebrovascular disease. To reduce examination time and exposure to radioactive gas, we assessed a count-based method with shorter continuous (15)O(2) gas inhalation. Twenty-five patients (66 +/- 13 [mean +/- SD] y old) with unilateral cerebrovascular stenoocclusive disease were examined by use of measurements of asymmetric oxygen extraction fraction (OEF) elevation. Dynamic PET scans of 1 min per frame were obtained starting 2 min after the beginning of (15)O(2) inhalation at a constant flow rate (740 MBq/min). Each subject also underwent C(15)O and H(2)(15)O PET with the bolus administration method. To evaluate the effects of different scan start times and durations during (15)O(2) inhalation, we extracted and summed individual (15)O(2) PET data from the dynamic (15)O(2) dataset. Count-based OEF (cbOEF) images were calculated from (15)O(2) and H(2)(15)O PET images. The asymmetric indices (AI) of cbOEF (cbOEF-AI) were obtained from regions of interest drawn on territories of the bilateral middle cerebral artery. These AI were compared with the AI of quantitative OEF (qOEF-AI). The slopes of the regression lines and the coefficients of correlati...Continue Reading

References

Oct 1, 1988·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M SendaR H Ackerman
Dec 1, 1983·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·A A LammertsmaT Jones
Jul 1, 1996·Journal of Neurology, Neurosurgery, and Psychiatry·H YamauchiJ Kimura
Oct 3, 1998·JAMA : the Journal of the American Medical Association·R L GrubbW J Powers
Jul 4, 2001·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·H OkazawaH Shio

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