Abstract
Schizophrenia is a severe, chronic mental disorder. Schizophrenia is visualized as an accelerated cellular aging syndrome characterized by early onset of cardiovascular disease causing premature mortality. In human aging involves alterations in telomere length (TL). To investigate the presence of TL shortening in schizophrenia and psychiatric syndromes associated, this condition was studied in leukocytes (LTL) of a sample of patients suffering from schizophrenia and other psychotic disorders, and compared with a group of non-psychiatric controls. We explored the relationship between LTL and age, gender, and smoking habit with the aim to control whether these potential confounding factors may influence the rate of telomeres shortening. We also performed a new comprehensive meta-analysis including studies on LTL in schizophrenia patients compared to healthy subjects published in the last two years and the results of the present study. Our results suggest that a diagnosis of schizophrenia, more than gender, age, cigarette smoking or alcohol drinking, is the most important condition responsible of the LTL shortening. A strong LTL shortening was observed in patients affected by schizophrenia, Schizoaffective disorder, and Psychosis ...Continue Reading
Citations
Jul 30, 2019·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Ather Muneer, Fareed Aslam Minhas
Nov 24, 2019·International Journal of Molecular Sciences·Sandra Ackermann, Matthias Fischer
May 29, 2020·Pathology Oncology Research : POR·Marco BenatiGiuseppe Lippi
Jan 29, 2020·BMJ Open·Mirko ManchiaAlessio Squassina
Sep 13, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Alessio SquassinaBernardo Carpiniello
Sep 14, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Alish B PalmosTimothy R Powell
Aug 21, 2020·Scientific Reports·Antti-Jussi ÄmmäläTiina Paunio
Oct 21, 2018·Brain Sciences·Corona SolanaRaquel Tarazona
Mar 23, 2020·Biological Psychiatry·Albert T Higgins-ChenMorgan E Levine
Apr 18, 2021·L'Encéphale·C CorfdirF Schürhoff
May 5, 2021·Psychiatry Research·Franck SchürhoffAndrei Szöke
Apr 9, 2021·Human Molecular Genetics·Gita A PathakRenato Polimanti
May 30, 2021·Psychoneuroendocrinology·Antti-Jussi ÄmmäläIiris Hovatta
Jul 17, 2021·Psychoneuroendocrinology·Fernanda TalaricoSintia I Belangero
Sep 13, 2021·Acta Psychiatrica Scandinavica·Pedro L BallesterBenicio N Frey
Oct 11, 2021·Translational Psychiatry·Yen-Feng LinMing-Chyi Huang