Shot noise in ion channels.

Biochimica Et Biophysica Acta
P Läuger

Abstract

A theoretical treatment of electrical noise originating from the discontinuous movement of ions through pore-like channels in a membrane is given. Two simple models are considered, a port with a single energy barrier and a pore with a single binding site separated from the aqueous solutions by energy barriers on either side. The single-barrier pore acts as a white-noise source with a spectral density SJ of the current that is proportional to the total rate of jumps over the barrier. At voltages near the equilibrium potential of the permeable ion, SJ becomes equal to the spectral density of thermal (or Johnson) noise. On the other hand, in the limit of high voltages, SJ approaches the spectral density of a Schottky noise source. A similar behaviour is found for channels with a double barrier in the limit of low frequencies omega. At higher frequencies a dispersion of the spectral density near omega = 1/tau1 occurs, where tau1 is the average lifetime of the occupied state of the channel.

References

Mar 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·H M Fishman
Jul 6, 1973·Biochimica Et Biophysica Acta·P Läuger
Aug 9, 1972·Biochimica Et Biophysica Acta·V B Myers, D A Haydon
Sep 1, 1971·The Journal of Membrane Biology·B KettererP Läuger

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Citations

Jan 1, 1984·European Biophysics Journal : EBJ·P Läuger
Aug 1, 1981·Pflügers Archiv : European journal of physiology·O P HamillF J Sigworth
Dec 15, 1977·The Journal of Membrane Biology·H A Kolb, P Läuger
Jul 12, 1978·Biophysics of Structure and Mechanism·B Neumcke
Jan 1, 1985·Progress in Biophysics and Molecular Biology·K CooperP Wolynes
Oct 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·M B JacksonH Lecar
Feb 21, 1978·Biochimica Et Biophysica Acta·P Läuger
Dec 22, 2007·Nanomedicine·Ken HealyAlan P Morrison
Jul 18, 2018·Physical Review. E·Janaki ShethAlex J Levine
Jul 25, 2019·Physical Review. E·Janaki ShethAlex J Levine
Jan 3, 2019·Nano Letters·Siddharth ShekarKenneth L Shepard

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