PMID: 6106109Aug 30, 1980Paper

Should anti-D immunoglobulin be given antenatally?

Lancet
G H Tovey

Abstract

A survey of 246 Rh-negative expectant mothers who had Rh antibodies for the first time has shown that in about 50% sensitisation might have been prevented had anti-D immunoglobulin (Ig) been injected after delivery of the previous Rh-positive baby. Sensitisation of the other mothers could have been prevented only by giving anti-D Ig antenatally during pregnancy. Perinatal mortality and morbidity in Britain from Rh-haemolytic disease in first-affected babies is now so low that an attempt to eliminate Rh-haemolytic disease by giving anti-D Ig to all expectant Rh-negative mothers during the antenatal period is not cost effective. If all Rh-negative mothers who abort or give birth to an Rh-positive baby are injected with an adequate dose of anti-D Ig within 72 h of delivery, the small number of mothers in whom measures to prevent sensitisation have failed can be reduced by 50%.

Citations

Jan 31, 1981·Lancet
Jan 31, 1981·Lancet·I G McKeithA R Nicol
Oct 15, 1983·Lancet·L A Tovey
Feb 18, 1989·Lancet
Feb 12, 1981·The New England Journal of Medicine·S Davis
Jul 6, 1985·British Medical Journal·S J Urbaniak
Jun 24, 1989·BMJ : British Medical Journal·J G ThorntonJ S Scott
Sep 1, 1986·British Journal of Obstetrics and Gynaecology·L A Tovey
Feb 1, 1984·The Australian & New Zealand Journal of Obstetrics & Gynaecology·B F JonesR S Nanra
Mar 1, 1988·Indian Journal of Pediatrics·R Merchant, R Divekar

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