Should bladder biopsies be performed routinely after bacillus Calmette-Guérin treatment for high-risk superficial transitional cell cancer of the bladder?

European Urology
Laurent GuyThierry Lebret

Abstract

After endoscopic resection of high-grade superficial urothelial neoplasms (Ta, T1 or Tis), adjuvant bacillus Calmette-Guérin (BCG) therapy is performed routinely to avoid recurrence and/or progression. Vesical biopsies often are performed to assess the efficacy of treatment. The aim of our study was to evaluate the usefulness of these biopsies. During this retrospective bi-centre study, 130 patients who had undergone vesical high-grade tumour resection were included. There were 40 Ta associated with Tis in three cases, 87 T1 associated with Tis in 13 cases, and three isolated Tis. After BCG treatment, the following parameters were studied: cytoscopic findings, urine cytology and the histologic results of systematised biopsies. Urine cytology was positive (high-grade) for 26 patients and negative (normal or low-grade) for 104 patients. For the 26 patients with positive cytology, vesical flexible cystoscopy findings were considered suspicious in 18 patients and normal in eight patients. As for the 104 patients who presented negative cytology, cystoscopic findings were considered negative in 76 patients and suspicious in 28 patients. In the present study, the sensitivity of cytology and cystoscopy in the detection of recurrence af...Continue Reading

References

Apr 1, 1992·The Journal of Urology·H W HerrH F Oettgen
Sep 1, 1988·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·H W HerrW F Whitmore
Oct 15, 1985·Cancer·U A ShenoyG B Schumann
Jun 29, 1999·Cancer·S BastackyW M Murphy
Dec 26, 2001·European Urology·W OosterlinckUNKNOWN Members of the EORTC GU Group
Feb 9, 2002·Urology·Neil M Skemp, Eduardo T Fernandes
Jun 18, 2003·Urologic Oncology·Ralph A HighshawRalph W deVere White
Jan 22, 2004·European Urology·J A Witjes

❮ Previous
Next ❯

Citations

May 19, 2007·American Journal of Clinical Pathology·Stephen S RaabKim R Geisinger
Oct 2, 2007·European Urology·Alexandre R Zlotta
Dec 24, 2009·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Jared M WhitsonBadrinath R Konety
Dec 5, 2008·International Journal of Urology : Official Journal of the Japanese Urological Association·Tomohiko HaraHideyasu Matsuyama
Nov 2, 2019·JAMA Oncology·Andrea B ApoloSundeep Agrawal
Jul 6, 2012·International Journal of Urology : Official Journal of the Japanese Urological Association·Andrew J LightfootMichael A O'Donnell
Oct 8, 2020·International Urology and Nephrology·Kimiharu TakamatsuMototsugu Oya

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bladder Carcinoma In Situ

Bladder Carcinoma In Situ is a superficial bladder cancer that occurs on the surface layer of the bladder. Discover the latest research on this precancerous condition in this feed.