Should Cannabinoids Be Added to Multimodal Pain Regimens After Total Hip and Knee Arthroplasty?

The Journal of Arthroplasty
Thomas R HickernellRoshan P Shah

Abstract

This study investigated the effects of dronabinol on pain, nausea, and length of stay following total joint arthroplasty (TJA). We retrospectively compared 81 consecutive primary TJA patients who received 5 mg of dronabinol twice daily in addition to a standard multimodal pain regimen with a matched cohort of 162 TJA patients who received only the standard regimen. A single surgeon performed all surgeries. Patient demographics, length of stay, opioid morphine equivalents (MEs) consumed, reports of nausea/vomiting, discharge destination, distance walked in physical therapy, and visual analog scale pain scores were collected for both groups. Student's t-tests as well as chi-square or Mann-Whitney U-tests were used for statistical comparisons. There were no significant differences between the 2 groups for age, gender, body mass index, American Society of Anesthesiologists score, anesthesia type, visual analog scale scores, distance walked with physical therapy, discharge disposition, or episodes of nausea/vomiting. The mean length of stay in the dronabinol group was significantly shorter at 2.3 ± 0.9 days versus 3.0 ± 1.2 days in the control group (P = .02). In the context of a shorter stay, the dronabinol group consumed significa...Continue Reading

Citations

Dec 5, 2019·The Journal of the American Academy of Orthopaedic Surgeons·Lindsay T Kleeman-ForsthuberJason M Jennings
May 31, 2020·Regional Anesthesia and Pain Medicine·Faraj W AbdallahRichard Brull
Oct 20, 2020·The Journal of Bone and Joint Surgery. American Volume·Jack H RuddellAlan H Daniels
May 15, 2020·The Journal of the American Academy of Orthopaedic Surgeons·Cesar D LopezThomas R Hickernell
Jan 1, 2021·Cannabis and Cannabinoid Research·Aaron GazendamHerman Johal
Jan 16, 2021·Journal of Orthopaedic Surgery and Research·Bradley J VivaceJeffrey L Gum
Feb 23, 2021·Arthroscopy, Sports Medicine, and Rehabilitation·Kamali A ThompsonKirk A Campbell
Mar 31, 2021·Rheumatic Diseases Clinics of North America·Oliver Hulland, Jessica Oswald
May 15, 2021·Journal of the American Academy of Orthopaedic Surgeons. Global Research & Reviews·David G DeckeyJoshua S Bingham
Jul 8, 2021·The Journal of Bone and Joint Surgery. American Volume·Joseph A KaramJavad Parvizi

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